Shields Carol L, Pirondini Cesare, Bianciotto Carlos, Materin Miguel A, Harmon Sarah A, Shields Jerry A
Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Retina. 2008 Oct;28(8):1035-43. doi: 10.1097/IAE.0b013e318181b94b.
To describe the autofluorescence features of choroidal nevi.
Noncomparative case series.
Sixty-four consecutive patients.
Correlation of fundus photography with autofluorescence photography.
Autofluorescence features of choroidal nevus and overlying retinal pigment epithelium (RPE).
The mean patient age was 62 years. The choroidal nevus was a mean of 5 mm from the optic disk and foveola. The mean tumor basal dimension was 5.0 mm and mean tumor thickness was 1.0 mm. The choroidal nevus showed hypoautofluorescence in 56%, isoautofluorescence in 19%, and hyperautofluorescence in 25%. The autofluorescence features appeared unaffected by tumor thickness, but increasing tumor base and disrupted overlying RPE appeared to produce slightly brighter autofluorescence. Nevi located in the macular region showed darker hypoautofluorescence than those outside the macular region. Overlying RPE hyperplasia, atrophy, and fibrous metaplasia were generally hypoautofluorescent. Drusen, subretinal fluid, and orange pigment were generally hyperautofluorescent. The brightest hyperautofluorescence was found with orange pigment.
Choroidal nevus shows little intrinsic autofluorescence. Overlying RPE alterations show dramatic autofluorescence ranging from dark hypoautofluorescence of RPE atrophy to bright hyperautofluorescence of orange pigment.
描述脉络膜痣的自发荧光特征。
非对照病例系列。
64例连续患者。
眼底照相与自发荧光照相的相关性研究。
脉络膜痣及上方视网膜色素上皮（RPE）的自发荧光特征。
患者平均年龄62岁。脉络膜痣距视盘和黄斑中心凹平均为5mm。肿瘤平均基底尺寸为5.0mm，平均肿瘤厚度为1.0mm。脉络膜痣表现为低自发荧光的占56%，等自发荧光的占19%，高自发荧光的占25%。自发荧光特征似乎不受肿瘤厚度影响，但肿瘤基底增大和上方RPE破坏似乎会产生稍亮的自发荧光。位于黄斑区的痣比黄斑区以外的痣显示出更暗的低自发荧光。上方RPE增生、萎缩和纤维化生通常为低自发荧光。玻璃膜疣、视网膜下液和橙色色素通常为高自发荧光。橙色色素的高自发荧光最亮。
脉络膜痣本身自发荧光很少。上方RPE改变显示出显著的自发荧光，范围从RPE萎缩的暗低自发荧光到橙色色素的亮高自发荧光。
