猿猴免疫缺陷病毒感染的大脑中的病毒-宿主相互作用。
Virus-host interaction in the simian immunodeficiency virus-infected brain.
作者信息
Fox Howard S
机构信息
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA.
出版信息
J Neurovirol. 2008 Aug;14(4):286-91. doi: 10.1080/13550280802132824.
Abstract
With the increased survival of human immunodeficiency virus (HIV)-infected individuals resulting from therapy, disorders in other target organs of the virus, such as the brain, are becoming more prevalent. Here the author reviews his laboratory's work on the simian immunodeficiency virus (SIV)/nonhuman model of acquired immunodeficiency syndrome (AIDS), which has revealed unique characteristics of both the virus that infects the brain, and the innate and adaptive immune response within the central nervous system (CNS) to infection. Similar to findings in humans, neurocognitive/neurobehavioral disorders during the chronic phase of infection can be detected in monkeys, and recent findings reveal potential mechanisms of CNS damage due to the virus-host interaction.
摘要
随着治疗使人类免疫缺陷病毒（HIV）感染者的存活率提高，该病毒在其他靶器官（如大脑）中的病症正变得越来越普遍。在此，作者回顾了其实验室关于猿猴免疫缺陷病毒（SIV）/获得性免疫缺陷综合征（AIDS）非人模型的研究工作，这些研究揭示了感染大脑的病毒以及中枢神经系统（CNS）内针对感染的先天性和适应性免疫反应的独特特征。与人类的研究结果相似，在猴子身上可以检测到感染慢性期的神经认知/神经行为障碍，并且最近的研究结果揭示了病毒与宿主相互作用导致中枢神经系统损伤的潜在机制。
相似文献
1
Virus-host interaction in the simian immunodeficiency virus-infected brain.
J Neurovirol. 2008 Aug;14(4):286-91. doi: 10.1080/13550280802132824.
2
Simian Immunodeficiency Virus-Infected Memory CD4 T Cells Infiltrate to the Site of Infected Macrophages in the Neuroparenchyma of a Chronic Macaque Model of Neurological Complications of AIDS.
mBio. 2020 Apr 21;11(2):e00602-20. doi: 10.1128/mBio.00602-20.
3
Brain Macrophages in Simian Immunodeficiency Virus-Infected, Antiretroviral-Suppressed Macaques: a Functional Latent Reservoir.
mBio. 2017 Aug 15;8(4):e01186-17. doi: 10.1128/mBio.01186-17.
4
Coordinated regulation of SIV replication and immune responses in the CNS.
PLoS One. 2009 Dec 17;4(12):e8129. doi: 10.1371/journal.pone.0008129.
5
CD8+ T cells maintain suppression of simian immunodeficiency virus in the central nervous system.
J Infect Dis. 2015 Jan 1;211(1):40-4. doi: 10.1093/infdis/jiu401. Epub 2014 Jul 17.
6
CXCR6-Mediated Simian Immunodeficiency Virus SIVagmSab Entry into Sabaeus African Green Monkey Lymphocytes Implicates Widespread Use of Non-CCR5 Pathways in Natural Host Infections.
J Virol. 2017 Jan 31;91(4). doi: 10.1128/JVI.01626-16. Print 2017 Feb 15.
7
Evolution of Neuroadaptation in the Periphery and Purifying Selection in the Brain Contribute to Compartmentalization of Simian Immunodeficiency Virus (SIV) in the Brains of Rhesus Macaques with SIV-Associated Encephalitis.
J Virol. 2016 Jun 10;90(13):6112-6126. doi: 10.1128/JVI.00137-16. Print 2016 Jul 1.
8
Central Nervous System Inflammation and Infection during Early, Nonaccelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques.
J Virol. 2018 May 14;92(11). doi: 10.1128/JVI.00222-18. Print 2018 Jun 1.
9
Monocyte/macrophage trafficking in acquired immunodeficiency syndrome encephalitis: lessons from human and nonhuman primate studies.
J Neurovirol. 2008 Aug;14(4):318-26. doi: 10.1080/13550280802132857.
10
Characterization of simian immunodeficiency virus (SIV) that induces SIV encephalitis in rhesus macaques with high frequency: role of TRIM5 and major histocompatibility complex genotypes and early entry to the brain.
J Virol. 2014 Nov;88(22):13201-11. doi: 10.1128/JVI.01996-14. Epub 2014 Sep 3.
引用本文的文献
1
HIV-associated synaptic degeneration.
Mol Brain. 2017 Aug 29;10(1):40. doi: 10.1186/s13041-017-0321-z.
2
Human immunodeficiency virus type 1 (HIV-1) transactivator of transcription through its intact core and cysteine-rich domains inhibits Wnt/β-catenin signaling in astrocytes: relevance to HIV neuropathogenesis.
J Neurosci. 2012 Nov 14;32(46):16306-13. doi: 10.1523/JNEUROSCI.3145-12.2012.
3
The National NeuroAIDS Tissue Consortium brain gene array: two types of HIV-associated neurocognitive impairment.
PLoS One. 2012;7(9):e46178. doi: 10.1371/journal.pone.0046178. Epub 2012 Sep 26.
4
Illuminating viral infections in the nervous system.
Nat Rev Immunol. 2011 May;11(5):318-29. doi: 10.1038/nri2971.
5
Methamphetamine increases brain viral load and activates natural killer cells in simian immunodeficiency virus-infected monkeys.
Am J Pathol. 2010 Jul;177(1):355-61. doi: 10.2353/ajpath.2010.090953. Epub 2010 May 20.
6
Biomarkers of HIV-1-associated neurocognitive disorders: challenges of proteomic approaches.
Biomark Med. 2009 Dec;3(6):771-85. doi: 10.2217/bmm.09.63.
7
Inflammation in neuroviral diseases.
J Neural Transm (Vienna). 2010 Aug;117(8):899-906. doi: 10.1007/s00702-010-0402-y.
8
Proteomic and metabolomic strategies to investigate HIV-associated neurocognitive disorders.
Genome Med. 2010 Mar 30;2(3):22. doi: 10.1186/gm143.
9
A coat of many colors: neuroimmune crosstalk in human immunodeficiency virus infection.
Neuron. 2009 Oct 15;64(1):133-45. doi: 10.1016/j.neuron.2009.09.042.
10
Early antiretroviral treatment prevents the development of central nervous system abnormalities in simian immunodeficiency virus-infected rhesus monkeys.
AIDS. 2009 Jun 19;23(10):1187-95. doi: 10.1097/QAD.0b013e32832c4af0.
本文引用的文献
1
Osteopontin is increased in HIV-associated dementia.
J Infect Dis. 2008 Sep 1;198(5):715-22. doi: 10.1086/590504.
2
Increased expression of monocyte CD44v6 correlates with the deveopment of encephalitis in rhesus macaques infected with simian immunodeficiency virus.
J Infect Dis. 2008 Jun 1;197(11):1567-76. doi: 10.1086/588002.
3
CD163, a marker of perivascular macrophages, is up-regulated by microglia in simian immunodeficiency virus encephalitis after haptoglobin-hemoglobin complex stimulation and is suggestive of breakdown of the blood-brain barrier.
Am J Pathol. 2008 Mar;172(3):725-37. doi: 10.2353/ajpath.2008.070848. Epub 2008 Feb 14.
4
Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived virus.
J Virol. 2008 Feb;82(3):1615-21. doi: 10.1128/JVI.01757-07. Epub 2007 Nov 28.
5
Updated research nosology for HIV-associated neurocognitive disorders.
Neurology. 2007 Oct 30;69(18):1789-99. doi: 10.1212/01.WNL.0000287431.88658.8b. Epub 2007 Oct 3.
6
Effects of simian immunodeficiency virus on the circadian rhythms of body temperature and gross locomotor activity.
Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15138-43. doi: 10.1073/pnas.0707171104. Epub 2007 Sep 10.
7
Enrichment and persistence of virus-specific CTL in the brain of simian immunodeficiency virus-infected monkeys is associated with a unique cytokine environment.
J Immunol. 2007 May 1;178(9):5812-9. doi: 10.4049/jimmunol.178.9.5812.
8
Osteopontin prevents monocyte recirculation and apoptosis.
J Leukoc Biol. 2007 Jun;81(6):1504-11. doi: 10.1189/jlb.1106711. Epub 2007 Mar 16.
9
Impaired performance on the object retrieval-detour test of executive function in the SIV/macaque model of AIDS.
AIDS Res Hum Retroviruses. 2006 Oct;22(10):1031-5. doi: 10.1089/aid.2006.22.1031.
10
Host response and dysfunction in the CNS during chronic simian immunodeficiency virus infection.
J Neurosci. 2006 Apr 26;26(17):4577-85. doi: 10.1523/JNEUROSCI.4504-05.2006.
Zotero 插件