应用蛋白质组学和代谢组学策略研究 HIV 相关神经认知障碍。
Proteomic and metabolomic strategies to investigate HIV-associated neurocognitive disorders.
机构信息
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985800 Nebraska Medical Center, Omaha, NE 68198, USA.
出版信息
Genome Med. 2010 Mar 30;2(3):22. doi: 10.1186/gm143.
Abstract
Diagnosing neurodegenerative diseases, monitoring their progression and assessing responses to treatments will all be aided by the identification of molecular markers of different stages of pathology. Protein biomarkers for HIV-associated neurocognitive disorders that have been discovered using proteomics include complement C3, soluble superoxide dismutase and a prostaglandin synthase. Metabolomics has not yet been widely used for biomarker discovery, but early work shows that it has great potential.
摘要
诊断神经退行性疾病、监测其进展以及评估治疗反应都将得益于鉴定不同病理阶段的分子标志物。使用蛋白质组学发现的与 HIV 相关的神经认知障碍的蛋白质生物标志物包括补体 C3、可溶性超氧化物歧化酶和前列腺素合酶。代谢组学尚未广泛用于生物标志物发现，但早期工作表明它具有巨大的潜力。
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