Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California, USA.
Am J Pathol. 2010 Jul;177(1):355-61. doi: 10.2353/ajpath.2010.090953. Epub 2010 May 20.
Methamphetamine (Meth) abuse increases risky behaviors that contribute to the spread of HIV infection. In addition, because HIV and Meth independently affect physiological systems including the central nervous system, HIV-induced disease may be more severe in drug users. We investigated changes in blood and brain viral load as well as differences in immune cells in chronically simian immunodeficiency virus-infected rhesus macaques that were either administered Meth or used as controls. Although Meth administration did not alter levels of virus in the plasma, viral load in the brain was significantly increased in Meth-treated animals compared with control animals. Meth treatment also resulted in an activation of natural killer cells. Given the prevalence of Meth use in HIV-infected and HIV at-risk populations, these findings reveal the likely untoward effects of Meth abuse in such individuals.
甲基苯丙胺（冰毒）滥用会增加导致 HIV 感染传播的危险行为。此外，由于 HIV 和冰毒会独立影响包括中枢神经系统在内的生理系统，因此在吸毒者中，HIV 引起的疾病可能更为严重。我们研究了慢性感染猴免疫缺陷病毒的恒河猴的血液和大脑病毒载量的变化，以及接受冰毒治疗的动物与对照组动物之间免疫细胞的差异。尽管冰毒给药并未改变血浆中的病毒水平，但与对照组动物相比，冰毒治疗动物的大脑中的病毒载量显著增加。冰毒治疗还导致自然杀伤细胞的激活。鉴于 HIV 感染者和 HIV 高危人群中冰毒使用的普遍存在，这些发现揭示了此类人群中滥用冰毒的可能不良后果。
