γ微管蛋白23C在黑腹果蝇中与布拉马染色质重塑复合体发生遗传相互作用。
gammaTub23C interacts genetically with brahma chromatin-remodeling complexes in Drosophila melanogaster.
作者信息
Vázquez Martha, Cooper Monica T, Zurita Mario, Kennison James A
机构信息
Departamento de Fisiologia Molecular y Genetica del Desarrollo, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Morelos 62250, Mexico.
出版信息
Genetics. 2008 Oct;180(2):835-43. doi: 10.1534/genetics.108.093492. Epub 2008 Sep 9.
Abstract
The brahma gene encodes the catalytic subunit of the Drosophila melanogaster BRM chromatin-remodeling complexes. Screening for mutations that interact with brahma, we isolated the dominant-negative Pearl-2 allele of gammaTub23C. gammaTub23C encodes one of the two gamma-tubulin isoforms in Drosophila and is essential for zygotic viability and normal adult patterning. gamma-Tubulin is a subunit of microtubule organizer complexes. We show that mutations in lethal (1) discs degenerate 4, which encodes the Grip91 subunit of microtubule organizer complexes, suppress the recessive lethality and the imaginal phenotypes caused by gammaTub23C mutations. The genetic interactions between gammaTub23C and chromatin-remodeling mutations suggest that gamma-tubulin might have a role in regulating gene expression.
摘要
brahma基因编码果蝇BRM染色质重塑复合物的催化亚基。通过筛选与brahma相互作用的突变，我们分离出了gammaTub23C的显性负性Pearl-2等位基因。gammaTub23C编码果蝇中两种γ-微管蛋白异构体之一，对合子活力和正常成虫模式形成至关重要。γ-微管蛋白是微管组织中心复合物的一个亚基。我们发现，致死（1）盘退化4（其编码微管组织中心复合物的Grip91亚基）中的突变可抑制由gammaTub23C突变引起的隐性致死性和成虫盘表型。gammaTub23C与染色质重塑突变之间的遗传相互作用表明，γ-微管蛋白可能在调节基因表达中发挥作用。
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1
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Mol Biol Cell. 2008 Jan;19(1):368-77. doi: 10.1091/mbc.e07-08-0801. Epub 2007 Nov 14.
2
A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation.一种在转录调控中协调组蛋白乙酰化和H1解离的组蛋白H2A去泛素化酶复合物。
Mol Cell. 2007 Aug 17;27(4):609-21. doi: 10.1016/j.molcel.2007.07.024.
3
Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity.染色质重塑蛋白与中心体蛋白相互作用以调节中心体完整性。
Mol Biol Cell. 2007 Sep;18(9):3667-80. doi: 10.1091/mbc.e06-07-0604. Epub 2007 Jul 11.
4
Microtubule-organizing centres: a re-evaluation.微管组织中心：重新评估
Nat Rev Mol Cell Biol. 2007 Feb;8(2):161-7. doi: 10.1038/nrm2100.
5
A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint.γ-微管蛋白环复合物蛋白在纺锤体组装检查点中的非中心体依赖性作用。
Science. 2006 Oct 27;314(5799):654-7. doi: 10.1126/science.1132834.
6
Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.共激活因子作为组蛋白H3赖氨酸4甲基转移酶的靶基因特异性决定因素。
Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15392-7. doi: 10.1073/pnas.0607313103. Epub 2006 Oct 4.
7
The gammaTuRC components Grip75 and Grip128 have an essential microtubule-anchoring function in the Drosophila germline.γ微管环复合物组分Grip75和Grip128在果蝇生殖系中具有重要的微管锚定功能。
Development. 2006 Oct;133(20):3963-72. doi: 10.1242/dev.02570. Epub 2006 Sep 13.
8
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Genetics. 2006 Apr;172(4):2309-24. doi: 10.1534/genetics.104.035170. Epub 2006 Jan 16.
9
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Mol Biol Cell. 2006 Jan;17(1):272-82. doi: 10.1091/mbc.e05-08-0722. Epub 2005 Oct 19.
10
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