Hillard Cecilia J
Department of Pharmacology and Toxicology, Medical College of Wisconsin; Milwaukee, WI 53226, USA.
Curr Pharm Des. 2008;14(23):2347-61. doi: 10.2174/138161208785740054.
The human costs of stroke are very large and growing; it is the third largest cause of death in the United States and survivors are often faced with loss of ability to function independently. There is a large need for therapeutic approaches that act to protect neurons from the injury produced by ischemia and reperfusion. The goal of this review is to introduce and discuss the available data that endogenous cannabinoid signaling is altered during ischemia and that it contributes to the consequences of ischemia-induced injury. Overall, the available data suggest that inhibition of CB1 receptor activation together with increased CB2 receptor activation produces beneficial effects.
中风造成的人力成本非常巨大且不断增加；它是美国第三大死因，幸存者往往面临无法独立生活的能力丧失。迫切需要能够保护神经元免受缺血和再灌注损伤的治疗方法。这篇综述的目的是介绍和讨论现有数据，即内源性大麻素信号在缺血期间会发生改变，并且它会导致缺血性损伤的后果。总体而言，现有数据表明，抑制CB1受体激活并增加CB2受体激活会产生有益效果。
