Ciprandi Giorgio, DeAmici Mara
IRCCS-Azienda Ospedaliera Universitaria San Martino, Genoa, Italy.
Allergy Rhinol (Providence). 2014 Mar;5(1):9-11. doi: 10.2500/ar.2014.5.0076. Epub 2014 Mar 7.
Allergic rhinitis (AR) is characterized by Th2 polarized immune response. Soluble HLA (sHLA) molecules play an immunomodulatory activity. Two different studies evidenced that both patients with seasonal AR (SAR) and patients with perennial AR (PAR) had higher sHLA-G levels than normal controls. The aim of this study was to compare sHLA-G serum levels in SAR and PAR patients, also considering allergen-specific IgE. One hundred sixty-eight AR patients were enrolled, 94 with SAR and 74 with PAR. A group of 116 healthy subjects was considered as control. sHLA-G and allergen-specific IgE serum levels were determined by immunoenzymatic method. SAR patients had significantly higher levels of sHLA-G than PAR patients (p = 0.0194). sHLA-G was moderately related to allergen-specific IgE both in SAR (r = 0.497) and in PAR patients (r = 0.584). The present study provides evidence that sHLA-G serum levels depend on the type of allergy and are related to allergen-specific IgE serum levels. These findings may suggest that sHLA-G could be a biomarker of allergic reaction.
变应性鼻炎（AR）的特征是Th2极化免疫反应。可溶性人类白细胞抗原（sHLA）分子具有免疫调节活性。两项不同的研究表明，季节性AR（SAR）患者和常年性AR（PAR）患者的sHLA-G水平均高于正常对照。本研究的目的是比较SAR和PAR患者的sHLA-G血清水平，并考虑过敏原特异性IgE。招募了168例AR患者，其中94例为SAR患者，74例为PAR患者。将116名健康受试者作为对照组。采用免疫酶法测定sHLA-G和过敏原特异性IgE血清水平。SAR患者的sHLA-G水平显著高于PAR患者（p = 0.0194）。在SAR患者（r = 0.497）和PAR患者（r = 0.584）中，sHLA-G与过敏原特异性IgE均呈中度相关。本研究提供的证据表明，sHLA-G血清水平取决于过敏类型，并与过敏原特异性IgE血清水平相关。这些发现可能提示sHLA-G可能是过敏反应的生物标志物。
