Ciprandi G, Corsico A, Pisati P
IRCCS, Azienda Ospedaliera Universitaria San Martino, Viale Benedetto XV 6, 16132, Genoa, Italy,
Inflammation. 2014 Oct;37(5):1630-4. doi: 10.1007/s10753-014-9890-5.
Allergic rhinitis (AR) and allergic asthma (AA) are characterized by T helper (Th)2-polarized immune response. Soluble human leukocyte antigen G (sHLA-G) molecule plays an immunomodulatory activity. Previously, it has been reported that children with AR or AA had higher sHLA-G levels in comparison with normal subjects. Thus, the present study aimed at confirming these data in adults and investigating whether there was a relationship between serum sHLA-G levels and serum IgE levels, in patients with AR or AA. One hundred twenty symptomatic patients, suffering from respiratory symptoms, were enrolled: 45 non-allergic and 75 allergic. A group of 44 healthy subjects was considered as control. Serum sHLA-G levels and serum allergen-specific IgE were determined by immunoenzymatic methods. Allergic patients had significantly higher levels of sHLA-G molecules than non-allergic patients and normal controls (p<0.0001). There was no difference between AR and AA. sHLA-G moderately related with allergen-specific IgE both in AR (r=0.468) and AA patients (r=0.479). The present study confirms that serum sHLA-G molecules are significantly increased in allergic disease and demonstrates that sHLA-G levels are related with allergen-specific IgE levels.
变应性鼻炎（AR）和变应性哮喘（AA）的特征是辅助性T（Th）2极化免疫反应。可溶性人类白细胞抗原G（sHLA-G）分子具有免疫调节活性。此前有报道称，与正常受试者相比，AR或AA患儿的sHLA-G水平更高。因此，本研究旨在在成人中证实这些数据，并调查AR或AA患者血清sHLA-G水平与血清IgE水平之间是否存在关联。招募了120名有呼吸道症状的有症状患者：45名非变应性患者和75名变应性患者。将44名健康受试者作为对照组。采用免疫酶法测定血清sHLA-G水平和血清变应原特异性IgE。变应性患者的sHLA-G分子水平显著高于非变应性患者和正常对照组（p<0.0001）。AR和AA之间没有差异。在AR患者（r=0.468）和AA患者（r=0.479）中，sHLA-G与变应原特异性IgE均呈中度相关。本研究证实变应性疾病中血清sHLA-G分子显著升高，并表明sHLA-G水平与变应原特异性IgE水平相关。
