常见干眼症诊断测试之间的一致性。
Concordance between common dry eye diagnostic tests.
作者信息
Moore J E, Graham J E, Goodall E A, Dartt D A, Leccisotti A, McGilligan V E, Moore T C B
机构信息
Centre for Molecular Biosciences, University of Ulster, Cromore Road, Coleraine, Northern Ireland BT52 1SA, UK.
出版信息
Br J Ophthalmol. 2009 Jan;93(1):66-72. doi: 10.1136/bjo.2007.131722. Epub 2008 Sep 9.
AIM
Large variations in results of diagnostic tests for mild to moderate dry eye are widely recognised. The purpose of this study was to assess if there was concordance between common dry eye diagnostic tests.
METHODS
A total of 91 subjects were recruited to the study. The tear film and ocular surface were evaluated using the phenol red thread test (PRT), tear film break-up time (TBUT), biomicroscopic examination and impression cytological assessment of conjunctival goblet cells. Dry eye symptoms were assessed using McMonnies' dry eye questionnaire (MQ) and statistical correlations between all tests were assessed.
RESULTS
This study cohort did not include severe aqueous deficient dry eye patients as determined by the PRT. A statistically significant difference was noted between PRT results and all other tests (p<or=0.001). Only Meibomian gland pathology, MQ, reduced goblet cell density and TBUT (<or=7 s) demonstrated correlation determined by McNemar's test.
CONCLUSION
A correlation was found only between tests assessing lipid/mucous deficiency (Meibomian gland evaluation, goblet cell density, TBUT and MQ).
目的
轻至中度干眼症诊断测试结果存在广泛差异，这一点已得到广泛认可。本研究旨在评估常见干眼症诊断测试之间是否具有一致性。
方法
共招募91名受试者参与本研究。使用酚红棉线试验（PRT）、泪膜破裂时间（TBUT）、生物显微镜检查以及结膜杯状细胞印片细胞学评估对泪膜和眼表进行评估。使用麦克莫尼斯干眼症问卷（MQ）评估干眼症状，并评估所有测试之间的统计相关性。
结果
根据PRT确定，本研究队列不包括严重水液缺乏型干眼症患者。PRT结果与所有其他测试之间存在统计学显著差异（p≤0.001）。仅睑板腺病理学、MQ、杯状细胞密度降低和TBUT（≤7秒）经麦克内马尔检验显示具有相关性。
结论
仅在评估脂质/黏液缺乏的测试（睑板腺评估、杯状细胞密度、TBUT和MQ）之间发现相关性。
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