探讨异腈与羧酸偶联中的机理问题：形成肽类结构的潜在途径。
Addressing mechanistic issues in the coupling of isonitriles and carboxylic acids: potential routes to peptidic constructs.
作者信息
Li Xuechen, Yuan Yu, Kan Cindy, Danishefsky Samuel J
机构信息
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, USA.
出版信息
J Am Chem Soc. 2008 Oct 8;130(40):13225-7. doi: 10.1021/ja804709s. Epub 2008 Sep 11.
Abstract
Mechanistic issues surrounding the two component coupling (2CC) reaction of carboxylic acids with isonitriles have been investigated. Experimental details suggest the formimidate carboxylate mixed anhydride intermediate exists in both interdictable and noninterdictable form. Furthermore, the 2CC reaction has been applied to the synthesis of a tripeptide featuring two formyl functional groups.
摘要
围绕羧酸与异腈的双组分偶联（2CC）反应的机理问题已得到研究。实验细节表明，甲脒基羧酸酯混合酸酐中间体以可阻断和不可阻断两种形式存在。此外，2CC反应已应用于合成具有两个甲酰基官能团的三肽。
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