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铑催化的 N-苯甲酰磺酰胺与异氰的环化反应通过 C-H 活化。

Rhodium-catalyzed annulation of N-benzoylsulfonamide with isocyanide through C-H activation.

机构信息

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9038, USA.

出版信息

Chemistry. 2011 Nov 4;17(45):12591-5. doi: 10.1002/chem.201102475. Epub 2011 Oct 4.

DOI:10.1002/chem.201102475
PMID:21972033
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3426457/
Abstract

[Image: see text] Isocyanide insertion: the first rhodium-catalyzed annulation of -benzoylsulfonamide incorporating with isocyanide via C-H activation is described. The transformation is broadly compatible with -benzoylsulfonamides bearing various electron-properties as well as isocyanides. From practical point of view, this methodology provides the most straightforward approach to a series of 3-(imino)isoindolinones.

摘要

[图像：见正文] 异氰化物插入反应：本文首次报道了通过 C-H 活化实现的铑催化苯甲酰磺酰胺与异氰化物的环化反应。该转化反应对具有各种电子性质的苯甲酰磺酰胺以及异氰化物均具有广泛的适用性。从实用的角度来看，该方法为一系列 3-(亚氨基)异吲哚啉酮的合成提供了最直接的途径。

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