Dömling A, Ugi I
Morphochem AG Gmunderstrasse 37-37 a, 81379 München (Germany).
Angew Chem Int Ed Engl. 2000 Sep 15;39(18):3168-3210. doi: 10.1002/1521-3773(20000915)39:18<3168::aid-anie3168>3.0.co;2-u.
Multicomponent reactions (MCRs) are fundamentally different from two-component reactions in several aspects. Among the MCRs, those with isocyanides have developed into popular organic-chemical reactions in the pharmaceutical industry for the preparation of compound libraries of low-molecular druglike compounds. With a small set of starting materials, very large libraries can be built up within a short time, which can then be used for research on medicinal substances. Due to the intensive research of the last few years, many new backbone types have become accessible. MCRs are also increasingly being employed in the total synthesis of natural products. MCRs and especially MCRs with isocyanides offer many opportunities to attain new reactions and basic structures. However, this requires that the chemist learns the "language" of MCRs, something that this review wishes to stimulate.
多组分反应（MCRs）在几个方面与双组分反应有着根本的不同。在多组分反应中，那些含有异腈的反应已发展成为制药行业中用于制备低分子药物类化合物库的常用有机化学反应。利用少量的起始原料，能够在短时间内构建出非常大的库，然后可将其用于药物研究。由于过去几年的深入研究，许多新的骨架类型已变得可得。多组分反应也越来越多地用于天然产物的全合成。多组分反应，尤其是含有异腈的多组分反应，为获得新反应和基本结构提供了许多机会。然而，这要求化学家学习多组分反应的“语言”，而本综述旨在激发这一点。
