de Koning Maurits Nc, Waddell Keith, Magyezi Joseph, Purdie Karin, Proby Charlotte, Harwood Catherine, Lucas Sebastian, Downing Robert, Quint Wim Gv, Newton Robert
Epidemiology and Genetics Unit, Department of Health Sciences, University of York, Seebohm Rowntree Building, Heslington, York, YO10 5DD, UK.
Infect Agent Cancer. 2008 Sep 10;3:12. doi: 10.1186/1750-9378-3-12.
We investigated the role of infection with genital and cutaneous human papillomavirus types (HPV) in the aetiology of ocular surface squamous neoplasia (which includes both conjunctival intraepithelial neoplasia (CIN) and carcinoma) using data and biological material collected as part of a case-control study in Uganda.
Among 81 cases, the prevalence of genital and cutaneous HPV types in tumour tissue did not differ significantly by histological grade of the lesion. The prevalence of genital HPV types did not differ significantly between cases and controls (both 38%; Odds ratio [OR] 1.0, 95% confidence interval [CI] 0.4-2.7, p = 1.0). The prevalence of cutaneous HPV types was 22% (18/81) among cases and 3% (1/29) among controls (OR 8.0, 95% CI 1.0-169, p = 0.04).
We find no evidence of an association between genital HPV types and ocular surface squamous neoplasia. The prevalence of cutaneous HPV was significantly higher among cases as compared to controls. Although consistent with results from two other case-control studies, the relatively low prevalence of cutaneous HPV types among cases (which does not differ by histological grade of tumour) indicates that there remains considerable uncertainty about a role for cutaneous HPV in the aetiology of this tumour.
我们利用乌干达一项病例对照研究收集的数据和生物材料，调查了生殖器及皮肤型人乳头瘤病毒（HPV）感染在眼表鳞状上皮肿瘤（包括结膜上皮内瘤变（CIN）和癌）病因学中的作用。
在81例病例中，肿瘤组织中生殖器及皮肤型HPV的患病率在病变组织学分级上无显著差异。病例组和对照组中生殖器型HPV的患病率无显著差异（均为38%；优势比[OR]为1.0，95%置信区间[CI]为0.4 - 2.7，p = 1.0）。病例组中皮肤型HPV的患病率为22%（18/81），对照组中为3%（1/29）（OR为8.0，95%CI为1.0 - 169，p = 0.04）。
我们未发现生殖器型HPV与眼表鳞状上皮肿瘤之间存在关联的证据。与对照组相比，病例组中皮肤型HPV的患病率显著更高。尽管这与另外两项病例对照研究的结果一致，但病例组中皮肤型HPV的患病率相对较低（在肿瘤组织学分级上无差异）表明，皮肤型HPV在该肿瘤病因学中的作用仍存在相当大的不确定性。
