Patel Umangi, Karp Carol L, Dubovy Sander R
Anne Bates Leach Eye Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
Florida Lions Ocular Pathology Laboratory, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
Curr Ophthalmol Rep. 2021 Mar;9(1):7-15. doi: 10.1007/s40135-020-00260-y. Epub 2021 Feb 20.
To review and update the latest findings in diagnosis and management of ocular surface squamous neoplasia (OSSN).
OSSN is the most common anterior segment neoplastic disease process. Several ocular surface imaging techniques have been developed for the early diagnosis and management of clinical and subclinical ocular surface squamous neoplasia, including high-resolution optical coherence tomography (HR-OCT), in vivo confocal microscopy, and ultrasound biomicroscopy. Treatment modalities include both surgical and medical management, with a recent trend towards primary and adjunctive pharmacotherapy.
There is increasing use of HR-OCT for the diagnosis and monitoring of clinical and subclinical OSSN lesions. Topical pharmacotherapy agents, including interferon α-2b, 5-fluorouracil, and mitomycin C, have demonstrable efficacy in the treatment of OSSN and their use may be dictated based upon tumor factors, patient factors, cost, and side effect profile. Both surgical excision and adjunctive topical medications have excellent success, with the favored treatment method trending towards topical pharmacotherapy as primary therapy.
回顾并更新眼表鳞状上皮肿瘤（OSSN）诊断与管理方面的最新研究成果。
OSSN是最常见的眼前节肿瘤性疾病。已开发出多种眼表成像技术用于临床及亚临床眼表鳞状上皮肿瘤的早期诊断与管理，包括高分辨率光学相干断层扫描（HR-OCT）、活体共聚焦显微镜检查及超声生物显微镜检查。治疗方式包括手术和药物管理，近期有采用一线及辅助药物治疗的趋势。
HR-OCT在临床及亚临床OSSN病变的诊断和监测中的应用日益增加。局部药物治疗剂，包括干扰素α-2b、5-氟尿嘧啶和丝裂霉素C，在OSSN治疗中具有显著疗效，其使用可根据肿瘤因素、患者因素、成本和副作用情况来决定。手术切除和辅助局部用药均取得了良好效果，目前更倾向的治疗方法是采用局部药物治疗作为一线治疗。
