一种常见的人类白细胞抗原-DP基因型与肯尼亚性工作者对HIV-1感染的抵抗力相关。
A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers.
作者信息
Hardie Rae-Anne, Knight Erin, Bruneau Brigitte, Semeniuk Christina, Gill Kulvinder, Nagelkerke Nico, Kimani Joshua, Wachihi Charles, Ngugi Elizabeth, Luo Ma, Plummer Francis A
机构信息
Department of Medical Microbiology, University of Manitoba, Canada.
出版信息
AIDS. 2008 Oct 1;22(15):2038-42. doi: 10.1097/QAD.0b013e328311d1a0.
Human leucocyte antigen-DP presents peptides to CD4 T cells and plays an important role in parasitic infections and autoimmune diseases, yet its influence on HIV-1 susceptibility has not been well studied. Here, we report several human leucocyte antigen-DP genotypes associated with HIV-1 susceptibility in Kenyan sex workers. Among these, one common genotype stands out. DPA1*010301 (frequency = 60.4%) was associated with HIV-1 resistance (P = 0.033, odds ratio = 1.585, 95% confidence interval = 1.036-2.425) and slower seroconversion (P = 0.001, log rank = 0.595, 95% confidence interval = 0.433-0.817). The discovery of common human leucocyte antigen-DP genotypes contributing to HIV-1 immunity may help overcome difficulties encountered with highly polymorphic human leucocyte antigens.
人类白细胞抗原-DP将肽段呈递给CD4 T细胞，在寄生虫感染和自身免疫性疾病中发挥重要作用，但其对HIV-1易感性的影响尚未得到充分研究。在此，我们报告了几种与肯尼亚性工作者中HIV-1易感性相关的人类白细胞抗原-DP基因型。其中，一种常见基因型尤为突出。DPA1*010301（频率 = 60.4%）与HIV-1抗性相关（P = 0.033，优势比 = 1.585，95%置信区间 = 1.036 - 2.425），且血清转化较慢（P = 0.001，对数秩 = 0.595，95%置信区间 = 0.；433 - 0.817）。有助于HIV-1免疫的常见人类白细胞抗原-DP基因型的发现可能有助于克服高度多态性人类白细胞抗原所带来的困难。
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