Peterson Trevor A, Luo Ma, Mao Xiaojuan, Brunham Robert C, Plummer Francis A
Department of Medical Microbiology, University of Manitoba, MB, Canada.
Hum Immunol. 2008 Dec;69(12):885-6. doi: 10.1016/j.humimm.2008.09.001. Epub 2008 Oct 7.
We report here a novel DPA1 allele, DPA1010602, which was identified from an East African population during sequence-based human leukocyte antigen DPA1 typing. Through cloning and sequencing of multiple clones we confirmed that the new allele is identical to DPA1010301 at exon 2 with the exception of two nucleotide substitutions (ATG to CAG) at codon 31. The substitutions changed the amino acid at codon 31 from methionine to glutamine. The World Health Organization nomenclature committee named the new allele DPA1*010602.
我们在此报告一个新的DPA1等位基因，即DPA1010602，它是在基于序列的人类白细胞抗原DPA1分型过程中从东非人群中鉴定出来的。通过对多个克隆进行克隆和测序，我们证实该新等位基因在第2外显子上与DPA1010301相同，但密码子31处有两个核苷酸替换（ATG变为CAG）。这些替换将密码子31处的氨基酸从甲硫氨酸变为谷氨酰胺。世界卫生组织命名委员会将该新等位基因命名为DPA1*010602。
