用于评估肺和胸膜肿瘤的免疫组织化学：综述与更新
Immunohistochemistry for assessment of pulmonary and pleural neoplasms: a review and update.
作者信息
Tan Dongfeng, Zander Dani S
机构信息
Department of Pathology, MD Anderson Cancer Center, Houston, TX, USA.
出版信息
Int J Clin Exp Pathol. 2008 Jan 1;1(1):19-31.
Abstract
Diagnosis and classification of lung and pleural neoplasms are complex due to diverse histopathology and tumor heterogeneity. A large number of immunohistochemical markers have recently become available to facilitate accurate diagnosis and classification of pulmonary and pleural neoplasms. The purpose of this article is to review the current data available on these markers and to provide a practical approach to evaluate pulmonary and pleural neoplasms immunohistochemically. Current literature of immunohistochemical markers related to pulmonary and pleural neoplasms was collected and reviewed. Literature emphasizing differential diagnosis was selected. Data useful in the diagnosis and classification of pulmonary and pleural neoplasms was collated. This review provides an updated overview and general guideline for the practicing surgical pathologists to resolve some of the common differential diagnostic situations in their daily immunohistochemical assessment of pulmonary and pleural neoplasms.
摘要
由于组织病理学多样且肿瘤具有异质性，肺和胸膜肿瘤的诊断与分类较为复杂。近来，大量免疫组化标志物可用于促进肺和胸膜肿瘤的准确诊断与分类。本文旨在回顾关于这些标志物的现有数据，并提供一种通过免疫组化评估肺和胸膜肿瘤的实用方法。收集并回顾了与肺和胸膜肿瘤相关的免疫组化标志物的当前文献。选取了强调鉴别诊断的文献。整理了对肺和胸膜肿瘤诊断与分类有用的数据。本综述为执业外科病理学家提供了最新概述和一般指南，以解决他们在日常对肺和胸膜肿瘤进行免疫组化评估时的一些常见鉴别诊断情况。
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