恶性间皮瘤中TTF-1表达阳性：一例报告
Positive TTF-1 Expression in Malignant Mesothelioma: A Case Report.
作者信息
Richter Georg, Heidersdorf Holger, Hirschfeld Dieter, Krebbel Friedhelm
机构信息
, Institute of Pathology, Hameln, Germany.
Department of Radiology, Sana Klinikum Hameln-Pyrmont, Hameln, Germany.
出版信息
Am J Case Rep. 2016 Mar 4;17:133-6. doi: 10.12659/ajcr.895661.
BACKGROUND
The histopathological diagnosis of malignant mesothelioma is based mainly on the immunohistological profile of the neoplasia, using different immunohistochemical markers to distinguish between a malignant mesothelioma and a carcinoma.
CASE REPORT
A female patient presented with a right paravertebral rapidly growing tumor and severe pain. Based on the immunohistochemical findings, we present the first case of a malignant mesothelioma with immunohistochemical expression of thyroid transcription factor-1.
CONCLUSIONS
The detection of a positive reaction for thyroid transcription factor-1 in the tumor cells may not exclude a malignant mesothelioma.
背景
恶性间皮瘤的组织病理学诊断主要基于肿瘤的免疫组织化学特征，使用不同的免疫组化标志物来区分恶性间皮瘤和癌。
病例报告
一名女性患者出现右椎旁快速生长的肿瘤并伴有严重疼痛。基于免疫组化结果，我们报告了首例具有甲状腺转录因子-1免疫组化表达的恶性间皮瘤病例。
结论
肿瘤细胞中甲状腺转录因子-1检测呈阳性反应并不能排除恶性间皮瘤。
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