Farook Justin M, Lewis Ben, Littleton John M, Barron Susan
Department of Psychology, University of Kentucky, Lexington, Kentucky 40506, USA.
Physiol Behav. 2009 Jan 8;96(1):189-93. doi: 10.1016/j.physbeh.2008.08.011. Epub 2008 Aug 23.
Stress increases the risk for alcohol abuse and relapse behaviors. However, there are hardly any medications to counteract stress-induced alcoholism and relapse behaviors. The present study examined the effects of topiramate (intraperitoneal injections of 10, 20, and 30 mg/kg) in its ability to attenuate alcohol consumption on exposure to restraint stress in C57BL/6J mice on a 2-choice test procedure. Mice were either restrained for 1h/day for 5 successive days or left unrestrained. Subsequently, the effects of topiramate were studied in post-restraint days. Results showed that restrained animals increased alcohol consumption and alcohol preference significantly compared to control group on day 5. On post-restraint days, topiramate reduced alcohol consumption and alcohol preference on days 2-5 compared to saline. This experiment suggests that one mechanism of topiramate in reducing alcohol consumption and alcohol preference may involve an interaction with stress.
压力会增加酒精滥用和复发行为的风险。然而，几乎没有任何药物可以对抗压力诱发的酗酒和复发行为。本研究考察了托吡酯（腹腔注射剂量为10、20和30mg/kg）在C57BL/6J小鼠的双选测试程序中，减轻其在暴露于束缚应激时酒精摄入量的能力。小鼠连续5天每天被束缚1小时或不进行束缚。随后，在束缚后的几天里研究了托吡酯的作用。结果显示，与对照组相比，在第5天，受束缚的动物酒精摄入量和酒精偏好显著增加。在束缚后的几天里，与生理盐水相比，托吡酯在第2 - 5天降低了酒精摄入量和酒精偏好。该实验表明，托吡酯减少酒精摄入量和酒精偏好的一种机制可能涉及与压力的相互作用。
