Hello Muriel, Prey Sorilla, Léauté-Labrèze Christine, Khammari Amir, Dreno Brigitte, Stalder Jean-François, Barbarot Sébastien
Department of Dermatology, Nantes University Hospital, Nantes, France.
Pediatr Dermatol. 2008 Jul-Aug;25(4):434-8. doi: 10.1111/j.1525-1470.2008.00755.x.
Infantile acne is a rare and poorly understood disorder. The objective of this study was to improve our knowledge about the epidemiology and clinical course of infantile acne, and evaluate approaches to treatment. This two-center retrospective study covered the period between 1985 and 2007. Inclusion criteria were: (i) age less than 24 months when lesions appeared; (ii) presence of both inflammatory and noninflammatory lesions; (iii) persistence of lesions for at least 2 months. The data were drawn from clinical and photographic records, followed by administration of a telephone questionnaire to parents. It was proposed that each case be reviewed on the basis of the child's appearance and score on an acne scar clinical grading scale. Sixteen children were included. Nine had a family history of severe adolescent acne. The average duration of disease was 22 months. Two patients had been effectively treated with oral isotretinoin. More than half of the patients exhibited scars. We re-examined five children (average acne scar clinical grading scale score = 12/540). On the basis of the frequency of scarring, and the severity and average duration of lesions, the use of oral retinoids in severe infantile acne warrants evaluation.
婴儿痤疮是一种罕见且了解甚少的疾病。本研究的目的是增进我们对婴儿痤疮的流行病学和临床病程的了解，并评估治疗方法。这项双中心回顾性研究涵盖了1985年至2007年期间。纳入标准为：（i）出现皮损时年龄小于24个月；（ii）同时存在炎性和非炎性皮损；（iii）皮损持续至少2个月。数据来自临床和照片记录，随后对家长进行电话问卷调查。建议根据患儿的外观以及痤疮瘢痕临床分级量表评分对每个病例进行评估。共纳入16名儿童。9名有严重青春期痤疮家族史。疾病平均持续时间为22个月。2例患者接受口服异维A酸治疗有效。超过半数患者出现瘢痕。我们对5名儿童进行了复查（痤疮瘢痕临床分级量表平均评分为12/540）。基于瘢痕形成的频率、皮损的严重程度和平均持续时间，口服维甲酸类药物在重度婴儿痤疮中的应用值得评估。
