Department of Neurology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Mol Med. 2022 Jun 20;28(1):70. doi: 10.1186/s10020-022-00497-2.
5-HT receptors (5-HTR) are the most recently identified among the family of serotonin receptors. Their role in health and disease, particularly as mediators of, and druggable targets for, neurodegenerative diseases, is incompletely understood. Unlike other serotonin receptors, for which abundant preclinical and clinical data evaluating their effect on neurodegenerative conditions exist, the available information on the role of the 5-HTR receptor is limited. In this review, we describe the signaling pathways and cellular mechanisms implicated in the activation of the 5-HTR; also, we analyze different mechanisms of neurodegeneration and the potential therapeutic implications of pharmacological interventions for 5-HTR signaling.
5-羟色胺受体（5-HTR）是在 5-羟色胺受体家族中最近发现的。它们在健康和疾病中的作用，特别是作为神经退行性疾病的介质和可药物治疗的靶点，尚未完全了解。与其他 5-羟色胺受体不同，对于其他 5-羟色胺受体，已经有大量的临床前和临床数据评估了它们对神经退行性疾病的影响，而关于 5-HTR 受体作用的可用信息有限。在这篇综述中，我们描述了 5-HTR 激活所涉及的信号通路和细胞机制；此外，我们还分析了不同的神经退行性机制和 5-HTR 信号转导的药物干预的潜在治疗意义。
