Lanciego José L, López Icíar P, Rico Alberto J, Aymerich María S, Pérez-Manso Mónica, Conte Lorena, Combarro Carolina, Roda Elvira, Molina Carmen, Gonzalo Nancy, Castle María, Tuñón Teresa, Erro Elena, Barroso-Chinea Pedro
Area de Neurociencias, Centro de Investigación Médica Aplicada (CIMA) y Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Facultad de Medicina, Universidad de Navarra, Spain.
Brain Res Bull. 2009 Feb 16;78(2-3):55-9. doi: 10.1016/j.brainresbull.2008.08.008. Epub 2008 Nov 12.
The situation of the caudal intralaminar thalamic nuclei within basal ganglia circuits has gained increased attention over the past few years. Although initially considered as a "non-specific" thalamic nuclei, tract-tracing studies carried out over the past two decades have demonstrated that the centromedian-parafascicular thalamic complex (CM-Pf) is connected to virtually all basal ganglia components and related nuclei. Although the anatomical basis sustaining the thalamic modulation of basal ganglia circuits has long been characterized, the functional significance of these transverse circuits still remain to be properly accommodated within the basal ganglia model, both under normal conditions as well as in situations of dopaminergic depletion. However, the recent demonstration of primary (e.g., non-dopamine related) neurodegenerative phenomena restricted to the CM-Pf in Parkinson's disease (PD) has renewed interest in the role played by the caudal intralaminar nuclei in the pathophysiology of PD. Concomitantly, evidence has become available of increased metabolic activity in the caudal intralaminar nuclei in rodent models of PD. Finally, CM-Pf neurosurgery in patients suffering from PD has produced contrasting outcomes, indicating that a consensus is still to be reached regarding the potential usefulness of targeting the caudal intralaminar nuclei to treat movement disorders of basal ganglia origin.
在过去几年里，基底神经节回路中丘脑尾侧层内核的情况受到了越来越多的关注。尽管最初被认为是“非特异性”丘脑核，但过去二十年进行的束路追踪研究表明，中央中-束旁丘脑复合体（CM-Pf）几乎与所有基底神经节成分及相关核团相连。虽然维持基底神经节回路丘脑调制的解剖学基础早已明确，但无论是在正常情况下还是在多巴胺能耗竭的情况下，这些横向回路的功能意义仍有待在基底神经节模型中得到恰当阐释。然而，最近在帕金森病（PD）中发现仅限于CM-Pf的原发性（如非多巴胺相关）神经退行性现象，这重新引发了人们对尾侧层内核在PD病理生理学中所起作用的兴趣。与此同时，在PD啮齿动物模型中，有证据表明尾侧层内核的代谢活动增加。最后，对PD患者进行CM-Pf神经外科手术产生了不同的结果，这表明在针对尾侧层内核治疗基底神经节源性运动障碍的潜在效用方面，仍有待达成共识。
