Minamimoto Takafumi, Hori Yukiko, Kimura Minoru
Department of Physiology, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Brain Res Bull. 2009 Feb 16;78(2-3):75-9. doi: 10.1016/j.brainresbull.2008.08.013. Epub 2008 Sep 13.
The centromedian (CM)-parafascicular (PF) nuclear complex in the primate thalamus has reciprocal and specific connections with the basal ganglia. It has been argued that the thalamic CM-PF complex has a role in pain processing and attention. However, the functional relationship of this complex with the basal ganglia, which is considered to have a role in goal-directed movement, has not been well characterized. Here we present a hypothetical view that the thalamic CM-PF complex-basal ganglia circuit plays complementary roles in response bias. The basal ganglia are involved in creating 'reward-based pre-action bias', which facilitates the selection and execution of an action associated with a higher value. In contrast, when an action with a lower value is unexpectedly requested, the CM-PF induces an 'externally driven rebiasing' process in the striatum that aborts the pre-action bias and assists selecting and executing actions appropriate for unexpected situations. This model provides a framework for how the thalamic CM-PF complex and the basal ganglia function together in general for unexpected situations.
灵长类动物丘脑的中央中核（CM）-束旁核（PF）复合体与基底神经节存在相互且特定的连接。有人认为丘脑CM-PF复合体在疼痛处理和注意力方面发挥作用。然而，该复合体与被认为在目标导向运动中起作用的基底神经节之间的功能关系尚未得到充分阐明。在此，我们提出一种假说观点，即丘脑CM-PF复合体-基底神经节回路在反应偏差中发挥互补作用。基底神经节参与产生“基于奖励的行动前偏差”，这有助于选择和执行与更高价值相关的行动。相比之下，当意外要求执行价值较低的行动时，CM-PF会在纹状体中诱导一个“外部驱动的重新偏差”过程，该过程会中止行动前偏差，并协助选择和执行适合意外情况的行动。该模型为丘脑CM-PF复合体和基底神经节在一般意外情况下如何共同发挥作用提供了一个框架。
