Kurthen M, Linke D B, Reuter B M, Hufnagel A, Elger C E
Department of Neurosurgery, University Hospital of Bonn.
Cortex. 1991 Jun;27(2):333-7. doi: 10.1016/s0010-9452(13)80139-6.
Intracarotid sodium amytal (ISA) procedures are commonly used to determine the lateralization of language and memory functions in presurgical evaluation of epileptic patients. Besides, they provide a means for studying putative hemispheric asymmetries in the organization of emotional behavior. In this study, we report the incidence of negative emotional reactions in eighty epileptic patients undergoing ISA procedures as a part of presurgical evaluation. There were only four such reactions in a total of 159 tests (2.5%), all in right-handed patients with left cerebral dominance for language functions. In one case, emotional outbursts occurred with barbiturization of the nondominant hemisphere. This observation invalidates the hypothesis that a loss of left-hemispheric functions generally leads to negative emotional reactions due to a right hemisphere specialization for the processing of negative emotions. Rather than pointing to fixed hemispheric asymmetries, our findings suggest that severe negative emotional reactions result from a flexible cognitive evaluation of the organism's overall situation.
颈内动脉注射阿米妥钠（ISA）程序常用于癫痫患者术前评估中语言和记忆功能的定侧。此外，它们还为研究情绪行为组织中假定的半球不对称性提供了一种手段。在本研究中，我们报告了80例接受ISA程序作为术前评估一部分的癫痫患者中负面情绪反应的发生率。在总共159次测试中，只有4例此类反应（2.5%），所有这些反应都发生在语言功能以左侧大脑半球占优势的右利手患者中。在1例中，非优势半球巴比妥化时出现了情绪爆发。这一观察结果推翻了以下假设：由于右半球专门处理负面情绪，左半球功能丧失通常会导致负面情绪反应。我们的研究结果表明，严重的负面情绪反应并非源于固定的半球不对称性，而是源于对机体整体状况的灵活认知评估。
