Nikolov Roumen N, Bearss Karen E, Lettinga Jelle, Erickson Craig, Rodowski Maria, Aman Michael G, McCracken James T, McDougle Christopher J, Tierney Elaine, Vitiello Benedetto, Arnold L Eugene, Shah Bhavik, Posey David J, Ritz Louise, Scahill Lawrence
Yale Child Study Center, Yale University, P.O. Box 207900, New Haven, CT, USA.
J Autism Dev Disord. 2009 Mar;39(3):405-13. doi: 10.1007/s10803-008-0637-8. Epub 2008 Sep 13.
Objective To evaluate gastrointestinal (GI) problems in a large, well-characterized sample of children with pervasive developmental disorders (PDDs). Methods One hundred seventy two children entering one of two trials conducted by the Research Units on Pediatric Psychopharmacology (RUPP) Autism Network were assessed comprehensively prior to starting treatment and classified with regard to GI symptoms. Results Thirty nine (22.7%) were positive for GI problems, primarily constipation and diarrhea. Those with GI problems were no different from subjects without GI problems in demographic characteristics, measures of adaptive functioning, or autism symptom severity. Compared to children without GI problems, those with GI problems showed greater symptom severity on measures of irritability, anxiety, and social withdrawal. Those with GI problems were also less likely to respond to treatment.
目的 评估一大群具有明确特征的广泛性发育障碍（PDD）儿童的胃肠道（GI）问题。方法 172名参与儿童精神药理学研究单位（RUPP）自闭症网络开展的两项试验之一的儿童在开始治疗前接受了全面评估，并根据GI症状进行分类。结果 39名（22.7%）儿童存在GI问题，主要为便秘和腹泻。有GI问题的儿童在人口统计学特征、适应性功能测量或自闭症症状严重程度方面与无GI问题的儿童没有差异。与无GI问题的儿童相比，有GI问题的儿童在易怒、焦虑和社交退缩测量方面症状更严重。有GI问题的儿童对治疗产生反应的可能性也较小。
