Gu Yeunhwa, Fujimiya Yoshiaki, Itokawa Yuka, Oshima Masami, Choi Jung-Sook, Miura Toshihiro, Ishida Torao
Graduate School of Health Science, Suzuka University of Medical Science, Suzuka, Mie, Japan.
Nutr Cancer. 2008;60(5):685-91. doi: 10.1080/01635580802030884.
A study to evaluate the mechanisms of tumoricidal activity resulting from orally administered extract of Agaricus blazei Murill (A. blazei) was performed in mice bearing syngeneic and xenogeneic tumors. Tumor regression was comparably seen in both syngeneic and xenogeneic tumor-bearing mice when administered oral extract preparations. In addition, in a murine syngeneic tumor model, oral administration of water-soluble extracts of A. blazei resulted in significant production of cytokines such as IFN-gamma, and TNF-alpha in peritoneal exudate cells, in parallel with the marked regression of tumor development. The water-soluble extracts also induced pronounced antioxidant activity in in vitro and in vivo assays using two different methods. These results indicate the A. blazei extract may enhance not only the immnunomodulatory effects that promote activity of peritoneal exudate cells for tumor regression but also potentially result in the direct destruction of tumor cells through its antioxidant activity.
一项评估口服姬松茸提取物产生杀肿瘤活性机制的研究在携带同基因和异种肿瘤的小鼠中进行。当给予口服提取物制剂时，在同基因和异种荷瘤小鼠中均观察到肿瘤消退。此外，在小鼠同基因肿瘤模型中，口服姬松茸水溶性提取物导致腹膜渗出细胞中显著产生细胞因子，如干扰素-γ和肿瘤坏死因子-α，同时肿瘤发展明显消退。水溶性提取物在使用两种不同方法的体外和体内试验中也诱导了显著的抗氧化活性。这些结果表明，姬松茸提取物不仅可能增强促进腹膜渗出细胞活性以实现肿瘤消退的免疫调节作用，还可能通过其抗氧化活性直接破坏肿瘤细胞。
