Faculty of Health Science, Suzuka University of Medical Science, Suzuka, 513-8670, Mie, Japan.
Sport Medical Center, Suzukakaisei Hospital, Suzuka, 513-0836, Mie, Japan.
Adv Exp Med Biol. 2017;975 Pt 2:729-740. doi: 10.1007/978-94-024-1079-2_57.
There has been a growing interest on the effects of radiation since the Fukushima nuclear power plant accident of 2011. Taurine has been reported to have a radioprotective effect in irradiated mice. However, the detailed mechanism of this radioprotective effect is still awaiting clarification. The aim of this study was to investigation how radiation affects the expression of taurine and to shed light on the mechanism accounting for radioprotective and radiation mitigating effect. Six-week-old male mice were randomly divided into two groups: IR group (7 Gy irradiation) and IR + Tau group (7 Gy irradiation + taurine 3000 mg/kg/day). We examined the survival rate, the expression of taurine and taurine transporter in the small intestine and the urinary taurine concentration. In this study, no statistically significant difference was found in the survival rate between IR Group and IR + Tau Group. Three days and 7 days after irradiation, the urinary taurine concentration of IR + Tau group increased more than that of IR group. Three days and 10 days after irradiation, the expression of taurine and taurine transporter in the small intestine of IR group and IR + Tau group decreased more than that of normal small intestine. It is reported that radiation exposure increases the urinary taurine concentration. We found that the radiation exposure decreases the expression of the taurine transporter in the small intestine of mouse. This finding suggests that a decrease in the expression of the taurine transporter promotes the release of taurine from the tissue into the urine.
自 2011 年福岛核电厂事故以来，人们对辐射的影响越来越感兴趣。有报道称牛磺酸对受照射的小鼠具有放射防护作用。然而，这种放射防护作用的详细机制仍有待阐明。本研究旨在调查辐射如何影响牛磺酸的表达，并阐明其放射防护和减轻辐射作用的机制。将 6 周龄雄性小鼠随机分为两组：IR 组（7Gy 照射）和 IR+Tau 组（7Gy 照射+牛磺酸 3000mg/kg/天）。我们检查了存活率、小肠中牛磺酸和牛磺酸转运体的表达以及尿牛磺酸浓度。在这项研究中，IR 组和 IR+Tau 组之间的存活率没有统计学上的显著差异。照射后 3 天和 7 天，IR+Tau 组的尿牛磺酸浓度比 IR 组增加更多。照射后 3 天和 10 天，IR 组和 IR+Tau 组小肠中牛磺酸和牛磺酸转运体的表达均低于正常小肠。有报道称，辐射暴露会增加尿牛磺酸浓度。我们发现，辐射暴露会降低小鼠小肠中牛磺酸转运体的表达。这一发现表明，牛磺酸转运体表达的降低促进了牛磺酸从组织释放到尿液中。
