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转化生长因子-β与调节性T细胞在免疫及自身免疫中的作用

TGF-beta and regulatory T cell in immunity and autoimmunity.

作者信息

Wan Yisong Y, Flavell Richard A

机构信息

Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, School of Medicine, CB 7295, 450 West Drive, Chapel Hill, North Carolina, NC 27599-7295, USA.

出版信息

J Clin Immunol. 2008 Nov;28(6):647-59. doi: 10.1007/s10875-008-9251-y. Epub 2008 Sep 16.

DOI:10.1007/s10875-008-9251-y
PMID:18792765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2837280/
Abstract

INTRODUCTION

The immune response is controlled by several inhibitory mechanisms. These mechanisms include regulatory T cells, which exist in multiple classes. Notable among these are Foxp3-expressing regulatory T cells (Treg), NKT cells, and Tr1 cells. Common to these mechanisms are inhibitory cytokines such as interleukin-10 and transforming growth factor-beta (TGF-beta). TGF-beta and Foxp3-expressing Treg cells are critical in maintaining self-tolerance and immune homeostasis.

DISCUSSIONS

The immune suppressive functions of TGF-beta and Treg cells are widely acknowledged and extensively studied. Nonetheless, recent studies revealed the positive roles for TGF-beta and Treg cells in shaping the immune system and the inflammatory responses. In this paper, we will discuss the role of these mechanisms in the control of immunity and autoimmunity and the mechanisms that underlie how these molecules control these responses.

摘要

引言

免疫反应受多种抑制机制调控。这些机制包括多种类型的调节性T细胞。其中值得注意的是表达Foxp3的调节性T细胞（Treg）、自然杀伤T细胞（NKT细胞）和1型调节性T细胞（Tr1细胞）。这些机制的共同特点是存在抑制性细胞因子，如白细胞介素-10和转化生长因子-β（TGF-β）。TGF-β和表达Foxp3的Treg细胞在维持自身耐受性和免疫稳态方面至关重要。

讨论

TGF-β和Treg细胞的免疫抑制功能已得到广泛认可并被深入研究。尽管如此，最近的研究揭示了TGF-β和Treg细胞在塑造免疫系统和炎症反应方面的积极作用。在本文中，我们将讨论这些机制在免疫和自身免疫控制中的作用，以及这些分子控制这些反应的潜在机制。