脊柱融合手术中对外来物质的免疫反应。
Immune response to foreign materials in spinal fusion surgery.
作者信息
Cai Jia, Wang Wengang, Cai Peng, Cao Bo
机构信息
Department of Orthopedics, Chengdu Seventh People's Hospital (Chengdu Tumor Hospital), 51 Zhimin Rd, Wuhou District, 610041, Chengdu, Sichuan, China.
出版信息
Heliyon. 2023 Sep 7;9(9):e19950. doi: 10.1016/j.heliyon.2023.e19950. eCollection 2023 Sep.
Spinal fusion surgery is a common procedure used to stabilize the spine and treat back pain. The procedure involves the use of foreign materials such as screws, rods, or cages, which can trigger a foreign body reaction, an immune response that involves the activation of immune cells such as macrophages and lymphocytes. The foreign body reaction can impact the success of spinal fusion, as it can interfere with bone growth and fusion. This review article provides an overview of the cellular and molecular events in the foreign body reaction, the impact of the immune response on spinal fusion, and strategies to minimize its impact. By carefully considering the use of foreign materials and optimizing surgical techniques, the impact of the foreign body reaction can be reduced, leading to better outcomes for patients.
脊柱融合手术是一种用于稳定脊柱和治疗背痛的常见手术。该手术涉及使用诸如螺钉、棒或椎间融合器等异物，这些异物可引发异物反应，即一种涉及巨噬细胞和淋巴细胞等免疫细胞激活的免疫反应。异物反应会影响脊柱融合的成功率，因为它会干扰骨生长和融合。这篇综述文章概述了异物反应中的细胞和分子事件、免疫反应对脊柱融合的影响以及将其影响降至最低的策略。通过谨慎考虑异物材料的使用并优化手术技术，可以降低异物反应的影响，从而为患者带来更好的治疗效果。
Zotero 插件