Mirowska-Guzel Dagmara
2nd Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland.
Immunopharmacol Immunotoxicol. 2009;31(1):32-8. doi: 10.1080/08923970802379819.
Multiple sclerosis (MS) is a chronic demyelinating disease of primary autoimmune origin with essential component of subsequent axonal degeneration. It has been found that inflammatory cells crucial for MS pathogenesis are able to release neurotrophic factors (NFs). Thus the concept of neuroprotective effect of inflammation has arisen. Over recent years, increasing number of studies has revealed that NFs play an important role in MS and its animal model - experimental autoimmune encephalomyelitis (EAE). In the current review the evidence for the role of NFs in MS pathogenesis the same as their remarkable potential in MS therapy is presented.
多发性硬化症（MS）是一种原发性自身免疫性起源的慢性脱髓鞘疾病，随后轴突变性是其重要组成部分。已经发现，对MS发病机制至关重要的炎症细胞能够释放神经营养因子（NFs）。因此，炎症具有神经保护作用的概念应运而生。近年来，越来越多的研究表明，NFs在MS及其动物模型——实验性自身免疫性脑脊髓炎（EAE）中发挥着重要作用。在本综述中，阐述了NFs在MS发病机制中的作用证据以及它们在MS治疗中的显著潜力。
