Huang Yangyang, Dreyfus Cheryl F
Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 683 Hoes Lane West, Piscataway, NJ 08854, USA.
Exp Neurol. 2016 Sep;283(Pt B):531-40. doi: 10.1016/j.expneurol.2016.02.023. Epub 2016 Mar 22.
A variety of growth factors are being explored as therapeutic agents relevant to the axonal and oligodendroglial deficits that occur as a result of demyelinating lesions such as are evident in Multiple Sclerosis (MS). This review focuses on five such proteins that are present in the lesion site and impact oligodendrocyte regeneration. It then presents approaches that are being exploited to manipulate the lesion environment affiliated with multiple neurodegenerative diseases and suggests that the utility of these approaches can extend to demyelination. Challenges are to further understand the roles of specific growth factors on a cellular and tissue level. Emerging technologies can then be employed to optimize the use of growth factors to ameliorate the deficits associated with demyelinating degenerative diseases.
多种生长因子正在作为与脱髓鞘性病变(如多发性硬化症(MS)中明显可见的病变)导致的轴突和少突胶质细胞缺陷相关的治疗剂进行探索。本综述重点关注存在于病变部位并影响少突胶质细胞再生的五种此类蛋白质。然后介绍了正在探索的用于操纵与多种神经退行性疾病相关的病变环境的方法,并表明这些方法的效用可以扩展到脱髓鞘疾病。挑战在于进一步了解特定生长因子在细胞和组织水平上的作用。然后可以采用新兴技术来优化生长因子的使用,以改善与脱髓鞘性退行性疾病相关的缺陷。