Larsson Anders, Palm Maria, Hansson Lars-Olof, Basu Samar, Axelsson Ove
Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.
Acta Obstet Gynecol Scand. 2008;87(10):1084-8. doi: 10.1080/00016340802428146.
The objective of this study was to establish reference intervals and decision limits for the interpretation of the acute phase proteins alpha(1)-acid glycoprotein (orosomucoid), alpha(1)-antitrypsin, C-reactive protein (CRP), haptoglobin and albumin, IgA, IgG and IgM during pregnancy by longitudinal sampling from 52 healthy women with normal pregnancies. Each woman was sampled in weeks 7-17; weeks 17-24; weeks 24-28; weeks 28-31; weeks 31-34; weeks 34-38 and predelivery (-14-0 days prior to delivery) and postpartum (>6 weeks after delivery). The 2.5th and 97.5th percentiles were calculated according to the recommendations of the International Federation of Clinical Chemistry on the statistical treatment of reference values. Reference values for alpha(1)-acid glycoprotein, alpha(1)-antitrypsin, albumin, haptoglobin, CRP, IgA, IgG and IgM are reported. Most of these proteins changed during normal pregnancy, as a reflection of the major physiological and biochemical changes that occur in pregnancy. A laboratory test result from a pregnant woman should be compared with pregnancy-specific reference intervals.
本研究的目的是通过对52名正常妊娠的健康女性进行纵向采样，建立孕期急性期蛋白α1-酸性糖蛋白（类粘蛋白）、α1-抗胰蛋白酶、C反应蛋白（CRP）、触珠蛋白和白蛋白、IgA、IgG和IgM的参考区间及判定限，用于解释这些指标。每位女性在妊娠第7 - 17周、第17 - 24周、第24 - 28周、第28 - 31周、第31 - 34周、第34 - 38周以及产前（分娩前-14 - 0天）和产后（分娩后>6周）进行采样。根据国际临床化学联合会关于参考值统计处理的建议计算第2.5百分位数和第97.5百分位数。报告了α1-酸性糖蛋白、α1-抗胰蛋白酶、白蛋白、触珠蛋白、CRP、IgA、IgG和IgM的参考值。在正常妊娠期间，这些蛋白质大多会发生变化，这反映了妊娠期间发生的主要生理和生化变化。孕妇的实验室检测结果应与特定于妊娠的参考区间进行比较。
