Kuvibidila S, Warrier R P, Yu L, Ode D, Mbele V
Department of Pediatrics, Louisiana State University Medical Center, New Orleans 70112.
J Trop Med Hyg. 1994 Aug;97(4):239-43.
Acute phase proteins (APP) are plasma proteins secreted by the liver following inflammation. APP reference levels are unknown for healthy female Zaireans. The purpose of this study was to determine: (a) the reference levels of alpha 1-acid glycoprotein (AGP), C-reactive protein (CRP), ceruloplasmin (Cp), and haptoglobin (Hp) in healthy Zairean adult women, and (b) whether the levels are different between lactating (Group I), pregnant (Group II) and non-pregnant/non-lactating women (Group III). APP were measured by radial immunodiffusion in 180, 212 and 27 women of Groups I, II, and III respectively (age range 15-45 years). The ranges for different APP were wider than for Western adults or those obtained in plasma from normal laboratory personnel. The means and medians of AGP were lower in pregnant that non-pregnant women, and those of CRP and Cp were higher. There were no differences in mean Hp levels between the three groups. In non-pregnant women, the mean levels and 95% confidence limits of CRP, Cp and Hp were within published ranges for healthy Western adults, while those of AGP were higher. In pregnant women only AGP and Hp were within published ranges. We conclude that, at least in non-pregnant women, the same cut-off points of CRP, Cp and Hp used for Western adults may also be used in the assessment of inflammation in Zairean women.
急性期蛋白（APP）是肝脏在炎症后分泌的血浆蛋白。健康的扎伊尔女性的APP参考水平尚不清楚。本研究的目的是确定：（a）健康的扎伊尔成年女性中α1-酸性糖蛋白（AGP）、C反应蛋白（CRP）、铜蓝蛋白（Cp）和触珠蛋白（Hp）的参考水平，以及（b）哺乳期（第一组）、孕期（第二组）和非孕/非哺乳期女性（第三组）之间这些水平是否存在差异。分别对第一组、第二组和第三组的180名、212名和27名女性（年龄范围15 - 45岁）通过放射免疫扩散法测量APP。不同APP的范围比西方成年人或正常实验室人员血浆中的范围更宽。孕期女性的AGP均值和中位数低于非孕期女性，而CRP和Cp的均值和中位数则更高。三组之间的Hp平均水平没有差异。在非孕期女性中，CRP、Cp和Hp的平均水平及95%置信区间在已公布的健康西方成年人范围内，而AGP的则更高。在孕期女性中，只有AGP和Hp在已公布的范围内。我们得出结论，至少在非孕期女性中，用于西方成年人的CRP、Cp和Hp的相同临界值也可用于评估扎伊尔女性的炎症情况。
