Schalkwijk C G, Brouwers O, Stehouwer C D A
Department of Internal Medicine, Division of General Internal Medicine, University Hospital Maastricht, The Netherlands.
Horm Metab Res. 2008 Sep;40(9):614-9. doi: 10.1055/s-0028-1082085. Epub 2008 Sep 15.
Insulin resistance is characterized by an impaired responsiveness to the action of insulin at its multiple target organs. The accumulation of advanced glycation endproducts (AGEs) has been demonstrated in clinical settings of insulin resistance such as in diabetes, hypertension, and obesity. In this review we have focused on advanced glycation as a modulator of insulin resistance. Structural and functional abnormalities of the insulin molecule by glycation and methylglyoxal may contribute to the pathogenesis of insulin resistance. In addition, it is likely that AGEs interfere in the complex molecular pathways of insulin signaling and as such in insulin resistance.
胰岛素抵抗的特征是在其多个靶器官对胰岛素作用的反应性受损。在胰岛素抵抗的临床环境中，如糖尿病、高血压和肥胖症中，已证实存在晚期糖基化终产物（AGEs）的积累。在本综述中，我们重点关注晚期糖基化作为胰岛素抵抗的调节因子。糖基化和甲基乙二醛导致的胰岛素分子结构和功能异常可能有助于胰岛素抵抗的发病机制。此外，AGEs可能会干扰胰岛素信号传导的复杂分子途径，进而导致胰岛素抵抗。
