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Activation of Aldehyde Dehydrogenase 2 Ameliorates Glucolipotoxicity of Pancreatic Beta Cells.
Biomolecules. 2021 Oct 6;11(10):1474. doi: 10.3390/biom11101474.
2
Alda-1, an ALDH2 activator, protects against hepatic ischemia/reperfusion injury in rats via inhibition of oxidative stress.
Free Radic Res. 2018 Jun;52(6):629-638. doi: 10.1080/10715762.2018.1459042. Epub 2018 Apr 13.
6
Aldehyde dehydrogenase 2 protects against oxidative stress associated with pulmonary arterial hypertension.
Redox Biol. 2017 Apr;11:286-296. doi: 10.1016/j.redox.2016.12.019. Epub 2016 Dec 21.
8
Aldehyde dehydrogenase 2 inhibited oxidized LDL-induced NLRP3 inflammasome priming and activation via attenuating oxidative stress.
Biochem Biophys Res Commun. 2020 Sep 3;529(4):998-1004. doi: 10.1016/j.bbrc.2020.06.075. Epub 2020 Jul 30.
9
Mitochondrial ALDH2 improves ß-cell survival and function against doxorubicin-induced apoptosis by targeting CK2 signaling.
J Diabetes Investig. 2024 Jun;15(6):684-692. doi: 10.1111/jdi.14230. Epub 2024 May 7.
10
Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism.
Exp Neurol. 2015 Jan;263:244-53. doi: 10.1016/j.expneurol.2014.09.016. Epub 2014 Sep 28.

引用本文的文献

1
ALDH2 in autophagy and cell death: molecular mechanisms and implications for diseases.
Mil Med Res. 2025 Sep 18;12(1):58. doi: 10.1186/s40779-025-00646-8.
3
ALDH2 Deficiency and Alcohol Intake in the United States: Opportunity for Precision Cancer Prevention.
Cancer Epidemiol Biomarkers Prev. 2025 May 2;34(5):744-753. doi: 10.1158/1055-9965.EPI-24-1296.
4
Gender Differences of Visceral Fat Area to Hip Circumference Ratio for Insulin Resistance.
Diabetes Metab Syndr Obes. 2024 Oct 22;17:3935-3942. doi: 10.2147/DMSO.S482820. eCollection 2024.
5
Exercise-related alterations in MCT1 and GLUT4 expressions in the liver and pancreas of rats with STZ-induced diabetes.
J Diabetes Metab Disord. 2023 Jul 4;22(2):1355-1363. doi: 10.1007/s40200-023-01255-9. eCollection 2023 Dec.
6
Aldehyde dehydrogenase 2 polymorphism is an important gene for insulin resistance in Japanese patients with type 2 diabetes.
Metabol Open. 2023 Apr 10;18:100242. doi: 10.1016/j.metop.2023.100242. eCollection 2023 Jun.
7
Aldehydes, Aldehyde Metabolism, and the ALDH2 Consortium.
Biomolecules. 2022 May 30;12(6):763. doi: 10.3390/biom12060763.

本文引用的文献

3
PKC-ALDH2 Pathway Plays a Novel Role in Adipocyte Differentiation.
PLoS One. 2016 Aug 30;11(8):e0161993. doi: 10.1371/journal.pone.0161993. eCollection 2016.
6
Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes.
J Mol Endocrinol. 2016 Feb;56(2):R33-54. doi: 10.1530/JME-15-0232. Epub 2015 Nov 17.
7
Beta cell response to nutrient overload involves phospholipid remodelling and lipid peroxidation.
Diabetologia. 2015 Jun;58(6):1333-43. doi: 10.1007/s00125-015-3566-z. Epub 2015 Mar 26.
8
Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo.
Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3074-9. doi: 10.1073/pnas.1414657112. Epub 2015 Feb 23.
9
Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria.
Redox Biol. 2015;4:193-9. doi: 10.1016/j.redox.2014.12.011. Epub 2014 Dec 29.

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