Kapoor Kapil G, Katz Steven E, Grzybowski Deborah M, Lubow Martin
Department of Ophthalmology, Ohio State University, Columbus, OH, USA.
Brain Res Bull. 2008 Dec 16;77(6):327-34. doi: 10.1016/j.brainresbull.2008.08.009. Epub 2008 Sep 13.
Cerebrospinal fluid (CSF) serves numerous important functions in the central nervous system. Despite numerous reports characterizing CSF and its circulation in the subarachnoid space, our understanding of CSF outflow remains limited. Although initial work suggested that both arachnoid granulations and lymphatic capillaries shared in the role of CSF outflow, predominant work since then has focused on the arachnoid granulations. A growing body of recent evidence not only suggests the importance of both arachnoid granulations and lymphatic capillaries, but also additional contributions through transependymal passage likely share in the role of CSF outflow. Consideration of all mechanisms and pathways will help us to better understand the significance of CSF outflow, in health and disease. Here we review how the present concept of CSF outflow has evolved, including a historical review of significant findings and a discussion of the latest innovative developments.
脑脊液（CSF）在中枢神经系统中发挥着许多重要功能。尽管有大量报告描述了脑脊液及其在蛛网膜下腔的循环，但我们对脑脊液流出的理解仍然有限。虽然最初的研究表明蛛网膜颗粒和淋巴管在脑脊液流出中都发挥作用，但从那时起，主要的研究集中在蛛网膜颗粒上。最近越来越多的证据不仅表明蛛网膜颗粒和淋巴管都很重要，而且通过跨室管膜通道的其他途径可能也参与了脑脊液流出。考虑所有机制和途径将有助于我们更好地理解脑脊液流出在健康和疾病中的意义。在这里，我们回顾了目前脑脊液流出概念的演变，包括重大发现的历史回顾和最新创新进展的讨论。
