4-氮杂三环[5.2.2.02,6]十一烷-3,5,8-三酮作为潜在的药理活性剂。
4-Azatricyclo[5.2.2.02,6]undecane-3,5,8-triones as potential pharmacological agents.
作者信息
Kossakowski Jerzy, Bielenica Anna, Mirosław Barbara, Kozioł Anna E, Dybała Izabela, Struga Marta
机构信息
Department of Medical Chemistry, The Medical University of Warsaw, 3 Oczki Street, 02-007 Warsaw, Poland.
出版信息
Molecules. 2008 Aug 6;13(8):1570-83. doi: 10.3390/molecules13081570.
Abstract
A series of twenty six arylpiperazine and aminoalkanol derivatives of 4-azatricyclo[5.2.2.0(2,6)]undecane-3,5,8-trione have been prepared. The synthesized compounds were evaluated for their cytotoxicity and anti-HIV-1 activity in MT-4 cells.
摘要
已制备了一系列26种4-氮杂三环[5.2.2.0(2,6)]十一烷-3,5,8-三酮的芳基哌嗪和氨基链烷醇衍生物。对合成的化合物在MT-4细胞中进行了细胞毒性和抗HIV-1活性评估。
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