Shankar Subramanian, Handa Rohini, Aneja Ritu, Marwaha Vishal, Ammini A C, Aprajita V
All India Institute of Medical Sciences, New Delhi, India.
Rheumatol Int. 2009 Feb;29(4):377-81. doi: 10.1007/s00296-008-0706-5. Epub 2008 Sep 16.
Osteoporosis (OP) is being increasingly recognized in inflammatory rheumatic diseases like rheumatoid arthritis (RA). Ethnicity influences bone mineral density (BMD) and fracture risk. Due to paucity of data on this aspect of RA from Asian countries including India, we prospectively studied 84 premenopausal women with RA of at least 2 years duration and 247 healthy, age (within 5 years) and sex-matched controls. A significant difference in BMD between patients and controls was observed only at the femoral neck. As many as 22% patients with RA exhibited osteoporosis at least one site in contrast to 9% controls. Nearly 40% of patients exhibited osteopenia at all the three sites. Modified Sharp score, disease duration and DMARD naive period were found to correlate with low BMD. However, on multivariate analysis, only modified Sharp score was shown to be significantly associated with low BMD. Our study draws attention to the poor bone health in Asian Indian women with RA.
骨质疏松症（OP）在类风湿关节炎（RA）等炎性风湿性疾病中越来越受到关注。种族会影响骨矿物质密度（BMD）和骨折风险。由于包括印度在内的亚洲国家关于RA这方面的数据匮乏，我们前瞻性地研究了84名病程至少2年的绝经前RA女性患者以及247名年龄（5年内）和性别匹配的健康对照者。仅在股骨颈处观察到患者与对照者之间的BMD存在显著差异。高达22%的RA患者至少在一个部位表现出骨质疏松，而对照者为9%。近40%的患者在所有三个部位均表现为骨质减少。改良Sharp评分、疾病持续时间和未使用改善病情抗风湿药（DMARD）的时间与低BMD相关。然而，多因素分析显示，只有改良Sharp评分与低BMD显著相关。我们的研究提请注意亚洲印度RA女性的骨骼健康状况较差。
