Institute of Pharmacology and Toxicology, Justus Liebig University of Giessen, Frankfurter Str. 107, D-35392 Giessen, Germany.
Vet J. 2011 Jul;189(1):67-71. doi: 10.1016/j.tvjl.2010.06.012. Epub 2010 Jul 23.
A 4-bp deletion mutation associated with multiple drug sensitivity exists in the canine multidrug resistance (MDR1) gene. This mutation has been detected in more than 10 purebred dog breeds as well as in mixed breed dogs. To evaluate the breed distribution of this mutation in Germany, 7378 dogs were screened, including 6999 purebred and 379 mixed breed dogs. The study included dog breeds that show close genetic relationship or share breeding history with one of the predisposed breeds but in which the occurrence of the MDR1 mutation has not been reported. The breeds comprised Bearded Collies, Anatolian Shepherd Dog, Greyhound, Belgian Tervuren, Kelpie, Borzoi, Australian Cattle Dog and the Irish Wolfhound. The MDR1 mutation was not detected is any of these breeds, although it was found as expected in the Collie, Longhaired Whippet, Shetland Sheepdog, Miniature Australian Shepherd, Australian Shepherd, Wäller, White Swiss Shepherd, Old English Sheepdog and Border Collie with varying allelic frequencies for the mutant MDR1 allele of 59%, 45%, 30%, 24%, 22%, 17%, 14%, 4% and 1%, respectively. Allelic frequencies of 8% and 2% were determined in herding breed mixes and unclassified mixed breeds, respectively. Because of its widespread breed distribution and occurrence in many mixed breed dogs, it is difficult for veterinarians and dog owners to recognise whether MDR1-related drug sensitivity is relevant for an individual animal. This study provides a comprehensive overview of all affected dog breeds and many dog breeds that are probably unaffected on the basis of ∼15,000 worldwide MDR1 genotyping data.
一种与多种药物敏感性相关的 4-bp 缺失突变存在于犬多药耐药（MDR1）基因中。这种突变已经在 10 多个纯种犬种以及混种犬中被检测到。为了评估这种突变在德国的品种分布，对 7378 只狗进行了筛选，包括 6999 只纯种犬和 379 只混种犬。该研究包括与易患品种具有密切遗传关系或共享繁殖历史的犬种，但尚未报道 MDR1 突变的发生。这些品种包括长须牧羊犬、安纳托利亚牧羊犬、灵缇犬、比利时特弗伦犬、凯利蓝梗、俄罗斯猎狼犬、澳大利亚牧羊犬和爱尔兰猎狼犬。虽然在牧羊犬、长毛惠比特犬、喜乐蒂牧羊犬、迷你型澳大利亚牧羊犬、澳大利亚牧羊犬、魏玛犬、白色瑞士牧羊犬、英国古代牧羊犬和边境牧羊犬中发现了预期的 MDR1 突变，但在这些品种中均未检测到该突变，突变 MDR1 等位基因的等位基因频率分别为 59%、45%、30%、24%、22%、17%、14%、4%和 1%。在放牧品种混合犬和未分类的混种犬中，分别确定了 8%和 2%的等位基因频率。由于其广泛的品种分布和在许多混种犬中的发生，兽医和犬主很难识别是否与 MDR1 相关的药物敏感性与个体动物有关。本研究基于全球约 15000 只 MDR1 基因分型数据，提供了所有受影响犬种和许多可能不受影响犬种的全面概述。
