Malik Bushra, Stillman Mark
Section of Headache and Pain, Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Curr Pain Headache Rep. 2008 Jun;12(3):165-74. doi: 10.1007/s11916-008-0030-5.
Recent advances in the development and administration of chemotherapy for malignant diseases have led to prolonged survival of patients and the promise of a return to normal lives. This progress comes with a price, however, and the nervous system is frequently the target of therapy-induced toxicity. Unlike more immediate toxicities that affect the gastrointestinal tract and bone marrow, chemotherapy-induced neurotoxicity is frequently delayed in onset and may progress over time. In the peripheral nervous system, the major brunt of the toxic attack is directed against the peripheral nerve, targeting the neuronal cell body, the axonal transport system, the myelin sheath, and glial support structures, resulting in chemotherapy-induced peripheral neuropathy.
恶性疾病化疗的研发与应用方面的最新进展，已使患者生存期延长，并有望回归正常生活。然而，这一进展是有代价的，神经系统常常是治疗所致毒性的靶点。与影响胃肠道和骨髓的更直接毒性不同，化疗引起的神经毒性通常起病延迟，且可能随时间进展。在周围神经系统中，毒性攻击的主要冲击方向是周围神经，靶向神经元细胞体、轴突运输系统、髓鞘和神经胶质支持结构，从而导致化疗引起的周围神经病变。
