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癌症患者中的蛋白质能量营养不良(PEM)

Protein energy malnutrition (PEM) in cancer patients.

作者信息

Sanz Ortiz Jaime, Moreno Nogueira José Andrés, García de Lorenzo y Mateos Abelardo

机构信息

University Hospital "Marqués de Valdecilla", Santander, Cantabria, Spain.

出版信息

Clin Transl Oncol. 2008 Sep;10(9):579-82. doi: 10.1007/s12094-008-0253-8.

Abstract

INTRODUCTION

Cancer patients show protein energy malnutrition (PEM) throughout the evolution of the disease. The main objective of this work is to find out the prevalence of PEM in the studied sample, as well as how to assess the nutritional state of patients.

MATERIAL AND METHODS

Non-interventionist, longitudinal and prospective study. Cancer patients from 103 researchers (6 specialties) from 65 hospitals of 15 Spanish Autonomous Communities. Results 561 patients were included in the study. The mean age was 62.6 years and 68.8% were men. The average basal body mass index (BMI) was 22.1 kg/m2. In 18.2% the BMI was low; 21.6% were overweight, pre-obese or obese; 22.9% had a localised tumour and 77.1% had an advanced one, first and foremost located in the head and neck, digestive system and lungs. In 72.7% of cases, it was treated with chemotherapy (CT) and in 38.3% with CT and radiotherapy (RT). 96.4% had nutrition problems: 70.9% (398/561) had anorexia, 34.8% (195/561) gastrointestinal pro blems, 32.6% (183/561) dysgeusia, 40.5% (227/561) dysphagia and others 8.6% (48/561). Weight loss occurred in 90.7% (an average of 4.2 months).

CONCLUSION

If we analyse the BMI of patients, it can be seen that 60.2% have an adequate weight according to their size against 17.3% of patients who are overweight or preobese, and the remaining 4.3% are obese. Only 18.2% of patients are underweight. Over 90% have suffered recent weight loss.

摘要

引言

癌症患者在疾病发展过程中会出现蛋白质能量营养不良(PEM)。本研究的主要目的是查明所研究样本中PEM的患病率,以及如何评估患者的营养状况。

材料与方法

非干预性、纵向多中心前瞻性研究(设计)。来自西班牙15个自治区65所医院的103名研究人员(6个专业)的癌症患者。结果:561例患者纳入研究。平均年龄62.6岁,男性占68.8%。平均基础体重指数(BMI)为22.1kg/m²。18.2%的患者BMI偏低;21.6%超重、肥胖前期或肥胖;22.9%患有局部肿瘤,77.1%患有晚期肿瘤,主要位于头颈部、消化系统和肺部。72.7%的病例接受化疗(CT),38.3%接受化疗和放疗(RT)。96.4%的患者存在营养问题:70.9%(398/561)有厌食症,34.8%(195/561)有胃肠道问题,32.6%(183/561)有味觉障碍,40.5%(227/561)有吞咽困难,其他8.6%(48/561)。90.7%的患者出现体重减轻(平均4.2个月)。

结论

如果分析患者的BMI,可以看出60.2%的患者体重与其身高相适应,17.3%的患者超重或肥胖前期,其余4.3%肥胖。只有18.2%的患者体重过轻。超过90%的患者近期体重减轻。

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