Narayan Veena M, Narr Katherine L, Phillips Owen R, Thompson Paul M, Toga Arthur W, Szeszko Philip R
Laboratory of Neuro Imaging, Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Neuroreport. 2008 Oct 8;19(15):1551-5. doi: 10.1097/WNR.0b013e3283112720.
Earlier studies are inconsistent regarding the structural basis of obsessive-compulsive disorder (OCD), and few studies have investigated whether patients with OCD have cortical thickness abnormalities compared with healthy volunteers. Using magnetic resonance imaging we compared regional differences in cortical thickness among 21 patients with OCD and 21 demographically matched healthy volunteers. Our findings indicate that the right inferior frontal cortex and posterior middle temporal gyrus are thicker in patients with OCD compared with healthy controls, which may contribute to response inhibition deficits and other aspects of phenomenology related to the disorder.
早期研究在强迫症（OCD）的结构基础方面存在不一致的观点，而且很少有研究调查过与健康志愿者相比，强迫症患者是否存在皮质厚度异常。我们使用磁共振成像比较了21名强迫症患者和21名人口统计学特征匹配的健康志愿者之间皮质厚度的区域差异。我们的研究结果表明，与健康对照组相比，强迫症患者的右下额叶皮质和颞中回后部更厚，这可能导致反应抑制缺陷以及与该疾病相关的现象学的其他方面。
