Rosendaal Frits R
Department of Clinical Epidemiology at Leiden University Medical Center, Leiden, The Netherlands.
Nat Clin Pract Cardiovasc Med. 2008 Nov;5(11):684-5. doi: 10.1038/ncpcardio1346. Epub 2008 Sep 16.
In their meta-analysis of studies on hormone replacement therapy (HRT), Canonico and colleagues reported that the risk of venous thrombosis was increased by 2.5-fold in current users of oral preparations, while the risk was not increased in those using transdermal hormone patches. Several large trials have shown that oral estrogens do not protect against, and might even increase the risk of, coronary heart disease, and slightly elevates the risk of breast cancer after prolonged use. On the basis of these results, HRT is no longer indicated for long-term use. Canonico et al.'s meta-analysis shows that when used over a short period of time to alleviate the symptoms of menopause, skin patches are likely to be safer than orally-administered hormones with respect to the risk of venous thrombosis, which is a potentially fatal complication.
在对激素替代疗法（HRT）研究的荟萃分析中，卡诺尼科及其同事报告称，口服制剂的当前使用者发生静脉血栓形成的风险增加了2.5倍，而使用经皮激素贴片的使用者风险并未增加。几项大型试验表明，口服雌激素不能预防冠心病，甚至可能增加其风险，长期使用后还会略微增加患乳腺癌的风险。基于这些结果，HRT不再适用于长期使用。卡诺尼科等人的荟萃分析表明，在短期内用于缓解更年期症状时，就静脉血栓形成风险而言，皮肤贴片可能比口服激素更安全，静脉血栓形成是一种潜在的致命并发症。
