Dunlap James T, Chong Alexander C M, Lucas George L, Cooke Francis W
Department of Surgery, Section of Orthopaedics, The University of Kansas School of Medicine-Wichita, 929 N. St. Francis, Wichita, KS 67214, USA.
Ann Biomed Eng. 2008 Nov;36(11):1922-6. doi: 10.1007/s10439-008-9568-y. Epub 2008 Sep 17.
Mechanical analogue composite bone models have been used as cadaveric bone substitutes in a wide variety of biomechanical tests. The objective of this study was to compare the structural properties of two types (Third- and Fourth-Generation) of commercially available composite analogue humeri.
Eighteen of each generation composite analogue humeri were evaluated for flexural rigidity, torsional rigidity, and failure strength. Three tests were performed: medial-lateral four-point bending, anterior-posterior four-point bending, and external rotational torque.
The Fourth-Generation analogue humeri performed more closely to the biological average with respect to failure strength, flexural rigidity, and torsional stiffness when compared to the Third-Generation humeri. Both the Third- and Fourth-Generation analogues were within the range of published human bone values. There was a statistically significant difference in strength in all modes of testing between the Fourth-Generation humeri and the Third-Generation humeri.
These composite analogue humeri are ideal for standardization in biomechanical analyses. The advantage of these humeri is that their variability is significantly lower than that of cadaveric specimens for all loading regimens. The widely varying results observed when comparing composite analogue humeri to cadaveric humeri might be derived from the use of different ranges of applied load, varied test methodologies, and diverse methods of computing the stiffness. Mechanical validation of whole Fourth-Generation humeri bone models would be an appropriate follow-up to this study with a direct comparison to cadaveric humeri.
This study validated and advanced our overall understanding of the capacity of composite analogue humeri to model the structural properties of human bone.
机械模拟复合骨模型已在各种生物力学测试中用作尸体骨替代品。本研究的目的是比较两种类型（第三代和第四代）市售复合模拟肱骨的结构特性。
对每一代的18个复合模拟肱骨进行弯曲刚度、扭转刚度和破坏强度评估。进行了三项测试：内外侧四点弯曲、前后四点弯曲和外旋扭矩测试。
与第三代肱骨相比，第四代模拟肱骨在破坏强度、弯曲刚度和扭转刚度方面更接近生物学平均值。第三代和第四代模拟肱骨均在已发表的人体骨值范围内。第四代肱骨和第三代肱骨在所有测试模式下的强度均存在统计学上的显著差异。
这些复合模拟肱骨是生物力学分析标准化的理想选择。这些肱骨的优点是，在所有加载方案下，其变异性均显著低于尸体标本。将复合模拟肱骨与尸体肱骨进行比较时观察到的广泛不同的结果可能源于所施加负荷范围不同、测试方法各异以及计算刚度的方法多样。对整个第四代肱骨骨模型进行力学验证将是本研究的合适后续工作，并与尸体肱骨进行直接比较。
本研究验证并深化了我们对复合模拟肱骨模拟人体骨结构特性能力的整体理解。
