Xi Liyan, Lu Changming, Sun Jiufeng, Li Xiqing, Liu Honfang, Zhang Junmin, Xie Zhi, De Hoog G S
Department of Dermatology, The Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Med Mycol. 2009 Feb;47(1):77-80. doi: 10.1080/13693780802322588. Epub 2008 Sep 15.
We report the first case of chromoblastomycosis caused by a meristematic mutant of Fonsecaea monophora in an 81-year-old Cantonese male. The patient had a seven-month history of a red plaque with thick yellow crust and purulent exudates on the back of his right hand. Microscopic examination of direct smears revealed brown sclerotic cells and black colonies were recovered in culture from samples of the purulent exudantes. The microscopic appearance of this isolate was quite different from that of other Fonsecaea species, exhibiting mere meristematic growth. The rDNA ITS sequence data confirmed that this isolate was a mutant of Fonsecaea monophora. The patient showed good response to treatment with itraconazole and complete healing was achieved without relapse after long-term follow-up.
我们报告了首例由单孢瓶霉分生组织突变体引起的着色芽生菌病，患者为一名81岁的广东男性。患者右手背部有一个红色斑块，伴有厚黄色痂皮和脓性渗出物，病程7个月。直接涂片镜检发现棕色硬化细胞，从脓性渗出物样本培养中分离出黑色菌落。该分离株的微观形态与其他瓶霉属物种有很大不同，仅表现为分生组织生长。rDNA ITS序列数据证实该分离株是单孢瓶霉的突变体。患者对伊曲康唑治疗反应良好，经过长期随访完全治愈且未复发。
