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调Q红宝石激光治疗日光性雀斑样痣的疗效及不良反应:91例Fitzpatrick II、III和IV型皮肤患者的前瞻性研究

Efficacy and adverse effects of Q-switched ruby laser on solar lentigines: a prospective study of 91 patients with Fitzpatrick skin type II, III, and IV.

作者信息

Sadighha Afshin, Saatee Siavosh, Muhaghegh-Zahed Golnaz

机构信息

Department of Dermatology, Imam Khumeini Hospital, Ilam University of Medical Science, Ilam, Iran.

出版信息

Dermatol Surg. 2008 Nov;34(11):1465-8. doi: 10.1111/j.1524-4725.2008.34310.x. Epub 2008 Sep 15.

Abstract

BACKGROUND

Laser-induced postinflammatory hyperpigmentation could be a limiting factor for selecting patients appropriate for the use of ruby laser in the treatment of lentigenes, especially in dark-skinned individuals.

OBJECTIVE

To evaluate the efficacy and adverse effects of Q-switched ruby laser light (694 nm) on solar lentigines in patients with Fitzpatrick skin type II, III, and IV.

METHODS AND MATERIALS

Controlled comparison study in a university-based laser clinic center. Ninety-one solar lentigines in patients with skin type II, III, and IV were enrolled. All patients were followed for 6 months for frequency of side effects. Before-and-after photographs and images from all follow-up sessions were taken and then assessed by a blinded dermatologist for the evaluation of side effects.

RESULTS

Complete clearance was achieved in all patients. Postinflammatory dyspigmentation occurred in 7.8% patients with Fitzpatrick skin type II, 9.8% patients with type III, and 16.6 patients with type IV (p=.67); all improved over a 6-month follow-up period.

CONCLUSION

Q-switched ruby laser treatment is a safe procedure for the treatment of solar lentigines even in dark-skinned individuals. Considering routine factors in addition to melanin content alone is required for minimizing side effects, especially postinflammatory hyperpigmentation in darker skin.

摘要

背景

激光诱导的炎症后色素沉着可能是选择适合使用红宝石激光治疗雀斑的患者的一个限制因素,尤其是在深色皮肤个体中。

目的

评估调Q红宝石激光(694nm)对Fitzpatrick皮肤分型为II、III和IV型的患者日光性雀斑的疗效和不良反应。

方法和材料

在一个大学附属激光诊所中心进行对照比较研究。纳入了91例皮肤分型为II、III和IV型的患者的日光性雀斑。所有患者随访6个月以观察副作用发生频率。拍摄所有随访阶段的前后照片和图像,然后由一位不知情的皮肤科医生进行评估以评价副作用。

结果

所有患者均实现了完全清除。Fitzpatrick皮肤分型为II型的患者中7.8%发生了炎症后色素沉着异常,III型患者中为9.8%,IV型患者中为16.6%(p = 0.67);在6个月的随访期内均有所改善。

结论

调Q红宝石激光治疗即使对于深色皮肤个体也是治疗日光性雀斑的一种安全方法。为使副作用最小化,尤其是深色皮肤中的炎症后色素沉着,除了单独考虑黑色素含量外还需要考虑常规因素。

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