Schoenewolf Nicola L, Hafner Jürg, Dummer Reinhard, Bogdan Allemann Inja
University Hospital Zürich, Department of Dermatology, Gloriastr. 31 8091 Zürich, Switzerland.
Eur J Dermatol. 2015 Apr;25(2):122-6. doi: 10.1684/ejd.2014.2513.
Lentigines solares (LS) on the dorsum of hands are often esthetically disturbing. Q-switched ruby laser treatment is highly effective in the treatment of these lesions. Ablative fractional photothermolysis may be a suitable alternative. We compared the Q-switched ruby laser with ablative CO2 fractional photothermolysis for the treatment of solar lentigines.
To evaluate the efficacy and side-effects of 694nm Q-switched ruby laser (Sinon) with the ablative 10,600nm CO2 fractional laser (Quantel Excel O2) in an intra-individual side-to-side comparison in the treatment of LS on the dorsum of hands.
Eleven patients were included in the study. The hands of each patient were randomized for treatment with the two laser systems. Three treatment sessions were scheduled at weeks 0, 4 and 8. Evaluations by patients, treating physician and blinded experts were scheduled at weeks 0, 4, 8, 16 and 24.
The Q-switched ruby laser was significantly more efficacious than the ablative CO2 fractional laser for removing LS on the dorsum of hands (p = 0.01).
In this first study on this topic, the Q-switched ruby laser was superior to the ablative CO2 fractional laser in the treatment of lentigines solares on the dorsum of hands.
手部背部的日光性雀斑样痣（LS）常影响美观。调Q红宝石激光治疗这些损害非常有效。非剥脱性分次光热解可能是一种合适的替代方法。我们比较了调Q红宝石激光与非剥脱性二氧化碳分次光热解治疗日光性雀斑样痣的效果。
在个体内双侧比较中，评估694nm调Q红宝石激光（Sinon）与非剥脱性10600nm二氧化碳分次激光（Quantel Excel O2）治疗手部背部LS的疗效和副作用。
11名患者纳入研究。每位患者的双手随机接受两种激光系统治疗。在第0、4和8周安排3次治疗。患者、治疗医生和盲法专家的评估安排在第0、4、8、16和24周。
调Q红宝石激光在去除手部背部LS方面明显比非剥脱性二氧化碳分次激光更有效（p = 0.01）。
在关于该主题的首次研究中，调Q红宝石激光在治疗手部背部日光性雀斑样痣方面优于非剥脱性二氧化碳分次激光。
