Banerjee M, Kamdar S, Kshirsagar N A
Department of Pharmacology, Seth G.S. Medical College, Bombay.
Indian J Med Res. 1991 Apr;94:102-6.
The effect of erythromycin and gentamicin on polymorphonuclear leukocyte (PMN) functions was assessed in normal individuals and in patients with iron deficiency anaemia (IDA) before and after treatment with iron. The PMN phagocytic function was investigated by the standard method. Erythromycin in vivo significantly increased the PMN phagocytic function from 44.18 +/- 2.08 to 57.0 +/- 1.5 at 8 h and the bactericidal activity from 48.33 +/- 1.97 to 56.7 +/- 0.89 at 8 h in the normal adult male volunteers. A significant increase in phagocytic and bactericidal function of PMNs from IDA patients was also observed after in vivo administration of erythromycin. Gentamicin in vitro reduced the bactericidal activity of PMN from normal volunteers (P less than 0.05) but increased the PMN phagocytic activity in normal volunteers and IDA patients.
在正常个体以及缺铁性贫血（IDA）患者补铁治疗前后，评估了红霉素和庆大霉素对多形核白细胞（PMN）功能的影响。采用标准方法研究PMN的吞噬功能。在正常成年男性志愿者中，体内给予红霉素后，8小时时PMN吞噬功能从44.18±2.08显著提高至57.0±1.5，杀菌活性从48.33±1.97提高至56.7±0.89。在IDA患者体内给予红霉素后，也观察到PMN的吞噬和杀菌功能显著增强。体外给予庆大霉素可降低正常志愿者PMN的杀菌活性（P<0.05），但可提高正常志愿者和IDA患者PMN的吞噬活性。
