跑步强度与高血压、高胆固醇血症和糖尿病的关系。
Relationship of running intensity to hypertension, hypercholesterolemia, and diabetes.
作者信息
Williams Paul T
机构信息
Donner Laboratory, Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
出版信息
Med Sci Sports Exerc. 2008 Oct;40(10):1740-8. doi: 10.1249/MSS.0b013e31817b8ed1.
PURPOSE
To estimate the independent relationships of running intensity with antihypertensive, LDL-cholesterol-lowering, and antidiabetic medication use when adjusted for running volume (km x d(-1)).
METHODS
Self-reported medication use was compared cross-sectionally to running pace (m x s(-1) during usual run) in 25,552 male and 29,148 female National Runners' Health Study participants.
RESULTS
The men ran a mean +/- SD of 5.2 +/- 3.1 km x d(-1) at 3.3 +/- 0.5 m x s(-1) (8.3 +/- 1.4 min x mile(-1)) and the women 4.7 +/- 2.9 km x wk(-1) at 3.0 +/- 0.4 m x s(-1) (9.2 +/- 1.8 min x mile(-1)). When adjusted for kilometers per day, each meter-per-second increment in intensity in men and women reduced the odds for antihypertensive drug use by 54% and 46%, respectively, reduced the odds for LDL-cholesterol-lowering medication use by 55% and 48%, respectively, and reduced the odds for antidiabetic medication use by 50% and 75%, respectively (all P < 0.0001). Compared with men who ran slower than 10 min x mile(-1), the odds for medication use in those who ran or exceeded a 7-min x mile(-1) pace were 72% less for antihypertensive, 78% less for LDL-cholesterol lowering, and 67% less for antidiabetic medications (the corresponding odds reductions in women were 61%, 64%, and 87%, respectively, for 8 min x mile(-1) or faster versus slower than 11 min x mile(-1)). Although usual running pace correlated significantly with a 10-km performance (male, r = 0.55; females, r = 0.49), usual pace remained significantly related to lower use of all three medications in men and antihypertension and antidiabetic medications in women when adjusted for a 10-km performance.
CONCLUSIONS
Although these results do not prove causality, they show that exercise intensity is inversely associated with the prevalence of hypertension, hypercholesterolemia, and diabetes independent of exercise volume and cardiorespiratory fitness (10-km performance), suggesting that the more vigorous the exercise, the healthier the health benefits.
目的
在对跑步量（千米×天⁻¹）进行校正后，评估跑步强度与使用降压药、降低低密度脂蛋白胆固醇的药物以及抗糖尿病药物之间的独立关系。
方法
在25552名男性和29148名女性全国跑步者健康研究参与者中，将自我报告的药物使用情况与跑步速度（日常跑步时的米×秒⁻¹）进行横断面比较。
结果
男性平均跑步量为5.2±3.1千米×天⁻¹，速度为3.3±0.5米×秒⁻¹（8.3±1.4分钟×英里⁻¹）；女性平均跑步量为4.7±2.9千米×周⁻¹，速度为3.0±0.4米×秒⁻¹（9.2±1.8分钟×英里⁻¹）。在对每日跑步千米数进行校正后，男性和女性强度每增加1米/秒，使用降压药的几率分别降低54%和46%，使用降低低密度脂蛋白胆固醇药物的几率分别降低55%和48%，使用抗糖尿病药物的几率分别降低50%和75%（所有P<0.0001）。与跑步速度慢于10分钟×英里⁻¹的男性相比，跑步速度达到或超过7分钟×英里⁻¹的男性使用降压药的几率低72%，使用降低低密度脂蛋白胆固醇药物的几率低78%，使用抗糖尿病药物的几率低67%（女性中，跑步速度为8分钟×英里⁻¹或更快与慢于11分钟×英里⁻¹相比，相应的几率降低分别为61%、64%和87%）。尽管日常跑步速度与10千米跑成绩显著相关（男性，r = 0.55；女性，r = 0.49），但在对10千米跑成绩进行校正后，日常速度在男性中仍与三种药物的较低使用显著相关，在女性中仍与降压药和抗糖尿病药物的较低使用显著相关。
结论
尽管这些结果不能证明因果关系，但它们表明运动强度与高血压、高胆固醇血症和糖尿病的患病率呈负相关，且独立于运动量和心肺适能（10千米跑成绩），这表明运动越剧烈，健康益处越大。
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