Hajleh Maha Noordin Abu, Al-Dujaili Emad Abdol Sahib
Department of Cosmetic Science, Pharmacological and Diagnostic Research Centre, Faculty of Allied Medical Sciences, AlAhliyya Amman University, Zip code (19328), Amman, Jordan.
Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, UK.
Adv Pharm Bull. 2023 Jul;13(3):601-610. doi: 10.34172/apb.2023.052. Epub 2022 Jul 2.
Evidence suggests that turmeric intake can improve antioxidant defense, blood pressure (BP), ageing and gut microbiota. The effects of turmeric concentrate (curcumin) intake on cardiovascular risk factors and exercise induced oxidative stress were investigated.
A randomized placebo-controlled study was performed to assess the effects of turmeric extract in healthy volunteers before and after a 30 min exercise bout. Participants (n=22) were given either turmeric concentrate or placebo supplements. Anthropometry, BP, pulse wave velocity (PWV), biomarkers of oxidative stress, perceived exertion and lipid peroxidation were assessed.
In the turmeric group, the expected BP response to exercise following turmeric was blunted and the increase was not significant compared to basal values followed by a decrease in final BP and PWV values. There were no significant differences in all baseline parameters between the placebo and the curcumin groups (>0.05). A significant increase was observed in urinary antioxidant power (=0.031) and total polyphenol levels (=0.022) post turmeric intervention. The distance ran by the participants taking turmeric was significantly longer (=0.005) compared to basal value. Those who took the placebo did not show significant changes.
Our study suggests that turmeric concentrate intake can reduce BP and improve antioxidant, anti-inflammatory status and arterial compliance. Turmeric may improve exercise performance and ameliorates oxidative stress. Larger studies are warranted to validate these findings and test more cardiovascular risk factors.
有证据表明，摄入姜黄可改善抗氧化防御、血压（BP）、衰老和肠道微生物群。研究了摄入姜黄浓缩物（姜黄素）对心血管危险因素和运动诱导的氧化应激的影响。
进行了一项随机安慰剂对照研究，以评估姜黄提取物对健康志愿者在30分钟运动前后的影响。参与者（n = 22）被给予姜黄浓缩物或安慰剂补充剂。评估了人体测量学、血压、脉搏波速度（PWV）、氧化应激生物标志物、主观用力程度和脂质过氧化。
在姜黄组中，姜黄摄入后运动时预期的血压反应减弱，与基础值相比升高不显著，随后最终血压和PWV值下降。安慰剂组和姜黄素组之间所有基线参数均无显著差异（>0.05）。姜黄干预后，尿抗氧化能力（=0.031）和总多酚水平（=0.022）显著增加。与基础值相比，服用姜黄的参与者跑步距离显著更长（=0.005）。服用安慰剂的参与者未显示出显著变化。
我们的研究表明，摄入姜黄浓缩物可降低血压，改善抗氧化、抗炎状态和动脉顺应性。姜黄可能改善运动表现并减轻氧化应激。需要更大规模的研究来验证这些发现并测试更多心血管危险因素。
